UNDERUTILIZATION OF ALBUMINURIA SCREENING IN ADULTS WITH DIABETES MELLITUS OR HYPERTENSION: A SYSTEMATIC REVIEW AND META-ANALYSIS

 

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UNDERUTILIZATION OF ALBUMINURIA SCREENING IN ADULTS WITH DIABETES MELLITUS OR HYPERTENSION: A SYSTEMATIC REVIEW AND META-ANALYSIS

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Mohamed
Albekery
Mohamed Albekery Malbekery@kfu.edu.sa King Faisal University Department of Pharmacy Practice Al-Ahsa Saudi Arabia *
Ibrahim Alhomoud i.alhomoud@qu.edu.sa Qassim University Department of Pharmacy Practice Qassim Saudi Arabia -
Lama Alabdulathim Lama.salman11@gmail.com Almoosa Rehabilitation Hospital Department of Pharmacy Hofuf Saudi Arabia -
Marwah Almajed Marwahalmajed@gmail.com Obeid Specialized Hospital Department of Pharmacy Hofuf Saudi Arabia -
Amjad Alobaid amjad0185@gmail.com King Faisal University Department of Pharmacy Practice Hofuf Saudi Arabia -
Manar Alomair manaralomair2000@gmail.com King Faisal University Department of Pharmacy Practice Hofuf Saudi Arabia -
Sukainah Al-Shehab Sukairx@gmail.com University College Dublin School of Medicine Dublin Ireland -
Khalid Alhasan kalhasan@ksu.edu.sa King Saud University Department of Pediatrics Riyadh Saudi Arabia -
Abdullah Al-Hamid aalhamid@kfu.edu.sa King Faisal University Department of Pharmacy Practice Hofuf Saudi Arabia -
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Guidelines recommend routine urine albumin-to-creatinine ratio (uACR) screening in patients with diabetes (annual) and hypertension (at least once, with follow-up annually if CKD is found). However, real-world adherence remains uncertain and appears suboptimal. This study aimed to quantify the global prevalence of albuminuria testing in high-risk adults with hypertension and/or diabetes.


We conducted a systematic review and meta-analysis of observational studies reporting the proportion of adults with diabetes mellitus, hypertension, or both who underwent albuminuria screening in routine care. Multiple databases were searched through Web of Science, PubMed, Google Scholar, and Scopus. Pooled testing prevalence was calculated using random-effects meta-analysis of proportions, with heterogeneity assessed by Cochran’s Q and I² statistics. Subgroup analyses examined differences by patient group, test modality, and country income level.

Thirty studies (from diverse countries and settings) met the inclusion criteria, involving over 29 million patients. Albuminuria testing rates were low in most settings. Overall, only about one in five high-risk patients underwent a uACR test in routine clinical practice. Pooled prevalence was approximately 22% (fixed-effect model dominated by a large U.S. dataset), and 49% (95% CI: 7–93%) in a random-effects model accounting for extreme between-study variability (I² ~100%). Testing uptake ranged from <5% in some systems to nearly 100% in protocolized programs. Subgroup comparisons showed higher rates in diabetes-focused and screening-driven studies, whereas hypertension cohorts had particularly low uptake.

Albuminuria screening remains underutilized among patients with hypertension or diabetes. This gap between guidelines and practice leads to delayed CKD detection and timely initiation of appropriate treatment.

Kewords