CLINICAL PROFILE ANDHISTOLOGICAL PATTERNS OF STERIOD RESISTANT NEPHROTIC SYNDROME IN CHILDREN

 

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https://storage.unitedwebnetwork.com/files/184/a28e312f4dc718bfef198df9375603d9.pdf
CLINICAL PROFILE ANDHISTOLOGICAL PATTERNS OF STERIOD RESISTANT NEPHROTIC SYNDROME IN CHILDREN

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Cho Cho
San
Cho Cho San drchocho.san@gmail.com University of Medicine (1) Yangon Children's Hospital Yangon Myanmar *
Khin Lei Lei Shein khinlaynge23@gmail.com University of Medicine (1) Yangon Children's Hospital Yangon Myanmar -
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Idiopathic steroid resistant nephrotic syndrome (iSRNS) represents about 10-20% of children with nephrotic syndrome and resulted with variable outcomes. Progression to chronic renal failure or end stage renal disease is almost certain after few years of diagnosis in children with iSRNS. In iSRNS, the underlying renal histopathological type effects the course and choice of treatment.


This was a hospital based descriptive study involving 26 patients. The study population included all cases of steroid resistant nephrotic syndrome who attended the renal unit of Yangon Children’s Hospital during the period of 2012-2017.

For old cases from 2012 to 2016, data were collected by reviewing medical records. For new cases, clinical presentations were recorded by doing history taking and physical examination.

The renal biopsy was taken by the paediatric nephrologist after getting informed consent. The ultrasound guided percutaneous renal biopsy was taken and histopathological examination was done by immunofluorescence and light microscope.


Sociodemographic characteristics

In this study, 26 participants were included and the mean age was 8.6 (±3) years. The most common age range was between 5 to 10 years (53.85%). 11.5% of study population was < 5 years old and 34.6% was > 10 years of age. The gender distribution in this study was 17 males (65.4%) and 9 females (34.6%).

This study revealed that the age of onset of children with non MCD associated iSRNS are older than MCD associated iSRNS. In this study, it was found that focal segmental glomerulosclerosis was the commonest histological type (38.4%) of iSRNS patients in Yangon Children Hospital.

This study found out that the atypical clinical presentations were common in non MCD types than MCD types but there was no statistically significance in association between atypical clinical presentations and histological types and it was due to small sample size. So, there was no clinical parameter or routine laboratory data that can predict the result of histological type.

 


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