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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Peritoneal dialysis (PD)–related infections (PDIs), which include peritonitis, exit-site infection, and tunnel infection, are severe complications that result in significant morbidity and mortality. PDIs are associated with adverse outcomes, including ultrafiltration failure, catheter loss or removal, and progression to encapsulating peritoneal sclerosis. Current international guidelines, including those by the International Society for Peritoneal Dialysis, recommend the extraperitoneal placement of the internal PD catheter cuff to prevent dialysate leakage, reduce cuff adhesion, and mitigate bacterial colonization. However, this recommendation is not supported by robust clinical evidence. This study aimed to confirm whether the intraperitoneal placement of the internal PD cuff is associated with PDIs.
This retrospective cohort study included 42 patients who initiated PD at Iwate Prefectural Isawa Hospital between April 1, 2010 and March 31, 2024. Patients transitioning from alternative renal replacement therapy modalities (e.g., hemodialysis or kidney transplantation) and those who developed PDIs within 3 months following PD initiation were excluded. The primary exposure was the placement of the internal cuff (extraperitoneal vs. intraperitoneal placement). The primary outcome was the development of any PDI (peritonitis, exit-site, or tunnel infection). Infection-free survival was evaluated using Kaplan–Meier analysis and the log-rank test. To evaluate the association of the internal cuff placement with the incidence of PDIs, three Cox proportional hazards regression models were created (using extraperitoneal placement as the reference) as followed: Model 1 (unadjusted), Model 2 (adjusted for age and sex), and Model 3 (adjusted for Model 2 variables + diabetes mellitus history and body mass index).
In total, 42 patients (29 extraperitoneal, 13 intraperitoneal) were included in the analysis. The median follow-up duration was 677.5 days (interquartile range: 370.5–1,142.0). Overall, 19 patients (45.2%) developed PDIs, with the intraperitoneal group have a higher PDI incidence (61.5% vs. 37.9%). Kaplan–Meier analysis showed that the intraperitoneal group had a significantly lower cumulative infection-free survival rate (p = 0.013). Intraperitoneal placement was significantly correlated with a higher risk of PDIs across all Cox regression models as follows: Model 1, (hazard ratio [HR] 3.17, 95% confidence interval [CI] 1.22–8.21, p = 0.018); Model 2 (HR 4.89, 95% CI 1.68–14.22, p = 0.003); and Model 3 (HR 6.89, 95% CI 1.91–24.86, p = 0.003).
Intraperitoneal placement of the internal PD catheter cuff was significantly associated with a higher risk of PDIs. Our results provide robust clinical evidence for favoring the extraperitoneal placement of the internal PD catheter cuff. As the participants’ data were obtained from a single center, the generalizability of the findings should be considered.
