CLINICAL PROFILE AND IN-HOSPITAL OUTCOMES OF PATIENTS WITH CHRONIC KIDNEY DISEASE FOR HEMODIALYSIS INITIATION IN A TERTIARY CARE HOSPITAL IN THE PHILIPPINES

 

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CLINICAL PROFILE AND IN-HOSPITAL OUTCOMES OF PATIENTS WITH CHRONIC KIDNEY DISEASE FOR HEMODIALYSIS INITIATION IN A TERTIARY CARE HOSPITAL IN THE PHILIPPINES

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Leidi Jayn
Sison
Leidi Jayn Sison deedeesison@gmail.com University of the Philippines - Philippine General Hospital Division of Nephrology Manila Philippines *
Margarita Rosario Peña mnpena1@up.edu.ph University of the Philippines - Philippine General Hospital Division of Nephrology Manila Philippines -
Amiel Rodas alrodas@up.edu.ph University of the Philippines - Philippine General Hospital Division of Nephrology Manila Philippines -
Anthony Russell Villanueva atvillanueva4@up.edu.ph University of the Philippines - Philippine General Hospital Division of Nephrology Manila Philippines -
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Chronic kidney disease (CKD) is the fourth leading cause of death in the Philippines. The number of Filipinos undergoing hemodialysis (HD) increased by 25% from 57,204 in 2023 to 71,615 in 2024. Despite this growing burden, data on the profile and outcomes of Filipino CKD patients initiating HD remain limited. The purpose of the study is to determine the sociodemographic, clinical, and laboratory profile of CKD patients initiating HD and identify risk factors for in-hospital mortality.

A retrospective descriptive cohort study was conducted including all adult CKD patients initiating HD during admission at the Philippine General Hospital from January 2022 to December 2024 through total enumeration sampling. Data were collected from electronic medical records and analyzed using univariate, bivariate, and logistic regression analyses in Stata 17.

A total of 169 patients were included. The mean age was 51.8 years (SD 14.3) with equal sex distribution and 91.1% belonging to low-income groups. The average hospital stay was 15.9 days (SD 16.5). Hypertension was the most common comorbidity (81.7%) and the leading CKD etiology (58%), followed by diabetes mellitus (42%). The time from CKD diagnosis to HD initiation spanned 29.8 months (SD 41.4). The majority of patients (87%) initiated hemodialysis on an emergency basis, mostly due to uremia (72.8%). Only 2.4% had a functional arteriovenous fistula at initiation. Laboratory findings associated with mortality included hypoalbuminemia (33.5 g/L, SD 7.1), elevated blood urea nitrogen (114.5 mg/dL, SD 51.9), and metabolic acidosis (bicarbonate 10.5 mmol/L, SD 5.4). Non-vascular access infections, including nosocomial pneumonia, ventilator-associated pneumonia, and urinary tract infection, were the most common complications (41.4%), followed by cardiovascular events (19.5%), and intradialytic hypotension (14.8%). In-hospital mortality rate was 33.1%, with infection accounting for 44.6% of deaths and cardiac events 42.9%. Bivariate analysis showed that pneumonia, male sex, hypoalbuminemia, lower baseline blood pressure, elevated blood urea nitrogen, hyperuricemia, and metabolic acidosis were associated with increased in-hospital mortality. However, multivariate logistic regression identified pneumonia as the only significant predictor (aOR 6.34, 95% CI 2.31–17.44; p<0.01).

The study demonstrated high morbidity and mortality rates among CKD patients initiating hemodialysis in a tertiary care hospital in the Philippines, most of whom began treatment under emergency conditions and without permanent vascular access. Hypertension emerged as the predominant CKD etiology, while pneumonia was the only significant predictor of in-hospital mortality. These findings highlight the critical need for timely outpatient nephrology referral, vascular access planning, and robust infection prevention strategies. These also provide valuable data to inform evidence-based health policy and clinical practice for improved patient outcomes and healthcare delivery.

Kewords