THE IMPORTANCE OF MEASURING SERUM MAGNESIUM LEVEL IN KIDNEY TRANSPLANT RECIPIENTS – AN INDIAN COHORT STUDY

 

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THE IMPORTANCE OF MEASURING SERUM MAGNESIUM LEVEL IN KIDNEY TRANSPLANT RECIPIENTS – AN INDIAN COHORT STUDY

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RP
Mathur
RP Mathur mathurrajan@gmail.com Institute of Liver & Biliary Sciences Department of Nephrology New Delhi India *
Chandani Bhagat chandani.bhagat@gmail.com Institute of Liver & Biliary Sciences Department of Nephrology New Delhi India -
Hari Shankar Meshram hsnephrology@gmail.com Institute of Liver & Biliary Sciences Department of Nephrology New Delhi India -
Saurabh Puri saurabhpuri119@gmail.com Institute of Liver & Biliary Sciences Department of Nephrology New Delhi India -
Bhavin Modasia modasiyabhavin@gmail.com Institute of Liver & Biliary Sciences Department of Nephrology New Delhi India -
Vishal Batheja vishalbatheja3@gmail.com Institute of Liver & Biliary Sciences Department of Nephrology New Delhi India -
Aditi Sharma aditi06nicoo@gmail.com Institute of Liver & Biliary Sciences Department of Nephrology New Delhi India -
Nidhi Yadav nidhiyadav918@gmail.com Institute of Liver & Biliary Sciences Department of Nephrology New Delhi India -
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Electrolyte disturbances are common following solid organ  transplantation. Hypomagnesemia is an electrolyte abnormality which is under recognized, under treated and has long term consequences following kidney transplantation. Hypomagnesemia has been  reported to develop  within the first few weeks following transplantation  associated with the use of CNI, PPIs, diuretics etc. There is scarcity of  data on prevalence of hypomagnesemia immediately after kidney  transplant and its correlation with CNI levels.

This was a single center  study in the Nephrology and Kidney Transplant Unit of the Institute of Liver & Biliary Sciences, New Delhi between January 2023 to July 2024.

During  the above period of 18 months, 120 patients of ESKD underwent kidney transplant of which 14 were DDKT and 106 were LDKT. The median age of patients was 37 years (IQR  with 78 percent male predominance). The incidence of hypomagnesemia was 15 & 90 percent after 10th day & 30th day post transplant. The median time to presentation was 7-10 days after transplant. There was no relation to CNI levels as 108 of 120 had hypomagnesemia  inspite of normal or low Tacrolimus level at the time of detection. 64 patients required intravenous Magnesium  supplementation and 44 required oral supplementation.

Hypomagnesemia is common in Kidney Transplant Recipients. The incidence of hypomagnesemia was high in this study. There was no  correlation with the occurrence of hypomagnesemia with CNI levels.

  Serum Magnesium level and its appropriate correction as a  routine practice in post transplant patients as it has many medium  and long term complications. 

 

 

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