Trends in Parenteral Nutrition Practices Among Hospitalized Patients with Chronic Kidney Disease Without Oral or Enteral Intake: A Nationwide Study in Japan

 

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https://storage.unitedwebnetwork.com/files/1099/8563b01438f2380290562183e9d96b07.pdf
Trends in Parenteral Nutrition Practices Among Hospitalized Patients with Chronic Kidney Disease Without Oral or Enteral Intake: A Nationwide Study in Japan

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Hideyuki
Kabasawa
Hideyuki Kabasawa hkabasawa@med.niigata-u.ac.jp Department of Clinical Nutrition Science, Kidney Research Center Niigata University Graduate School of Medical and Dental Sciences Niigata Japan *
Hisako Yoshida hisako.yoshida@omu.ac.jp Department of Medical Statistics Osaka Metropolitan University Graduate School of Medicine Osaka Japan -
Ayumi Shintani ayumi.shintani@omu.ac.jp Department of Medical Statistics Osaka Metropolitan University Graduate School of Medicine Osaka Japan -
Ryoto Hamamoto Hamamoto.Ryoto@otsuka.jp Medical Affairs Department, Research and Development Center Otsuka Pharmaceutical Factory, Inc Tokyo Japan -
Miyuki Tani Tani.Miyuki@otsuka.jp Medical Affairs Department, Research and Development Center Otsuka Pharmaceutical Factory, Inc Tokyo Japan -
Satoru Kamoshita kamoshitas@otsuka.jp Medical Affairs Department, Research and Development Center Otsuka Pharmaceutical Factory, Inc Tokyo Japan -
Michihiro Hosojima hoso9582@med.niigata-u.ac.jp Department of Clinical Nutrition Science, Kidney Research Center Niigata University Graduate School of Medical and Dental Sciences Niigata Japan -
 
 
 
 
 
 
 
 

Hospitalized patients often require parenteral nutrition (PN) when oral or enteral feeding is not feasible. Among those with chronic kidney disease (CKD), recent guidelines highlight the importance of the provision of adequate levels of energy, amino acids, and lipids in non-dialysis and dialysis patients, research on real-world adherence is scarce. This study investigated nationwide trends in PN prescriptions for hospitalized patients with CKD in Japan.

This retrospective cohort study was conducted using the Medical Data Vision database, which contains claims data from 502 acute care hospitals (approximately 27% of all hospitals in Japan). Adults (≥18 years) with non-dialysis CKD or on dialysis who received exclusive PN for >10 days were identified using ICD-10 codes and medical claim codes. Those lacking body weight data or with a mean PN energy of <100 kcal/day were excluded. Patients were grouped according to admission year (2012–2014, 2015–2017, 2018–2020, and 2021–2023) and dialysis status. The PN components (energy, amino acids, lipids, carbohydrates, water, and sodium) were calculated from the infusion records and standardized by body weight. Day 10 prescriptions and achievement rates for target energy (≥25 kcal/kg for non-dialysis and ≥30 kcal/kg for dialysis patients) and amino acids (≥0.6 g/kg for non-dialysis and ≥0.9 g/kg for dialysis patients) were compared across periods. Trends were evaluated using the Cochran–Armitage and Jonckheere–Terpstra tests (p<0.05) (UMIN ID: 000056795).

In total, 38,577 patients met the inclusion criteria (median age, 82 years [IQR, 74–88]; 35.4% female; median BMI, 20.4 [IQR, 18.0–23.1]). The median PN energy and amino acid doses during days 1–10 were 8.1 kcal/kg and 0.3 g/kg, respectively, with minimal lipid use. From 2012 to 2023, median day 10 energy decreased from 9.2 to 7.4 kcal/kg (trend p<0.001), while amino acid dosing showed small changes (~0.26 g/kg). Lipid use was negligible. The proportion achieving target energy declined (4.6%→3.5%; p<0.001), and protein target attainment remained low (~13%).

Over the past decade, PN has provided insufficient energy and amino acids to Japanese patients with CKD. Despite updated guidelines, nutritional support remains suboptimal, highlighting the need for improved PN management.

Kewords