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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Lupus nephritis (LN) is one of the most serious manifestations of systemic lupus erythematosus (SLE), characterized by immune complex–mediated glomerular injury that often leads to chronic kidney disease and long-term disability. Differences in histopathological classes influence prognostic outcomes and therapeutic responses. This study aimed to assess the clinical, laboratory, and histopathological profiles of LN patients and evaluate correlations between disease activity, chronicity, and lupus nephritis classes at a tertiary referral center in Indonesia.
A retrospective cross-sectional study was conducted at Kariadi Hospital, Semarang, Indonesia, from 2020 to 2025. Data were collected from 72 biopsy-proven LN patients, including demographic, clinical, and laboratory findings such as serum albumin, CRP, hemoglobin, anti-dsDNA, ANA, and estimated glomerular filtration rate (eGFR). Disease activity was evaluated using the SLE Disease Activity Index (SLEDAI), while renal biopsy samples were classified according to the ISN/RPS 2003 system. Histopathological activity and chronicity indices were calculated. One-way ANOVA was applied to analyze differences among LN classes, considering p < 0.05 as statistically significant.
The mean age was 25.9 ± 12.1 years, predominantly female (84.7%). The average BMI was 22.1 ± 2.7, with 23.4% underweight and 28.1% overweight or obese. Anemia was present in 77.9% of patients, and hypoalbuminemia (mean 2.42 ± 0.51 g/L) was common. The average SLEDAI score was 12.3 ± 8.1, with moderate, high and very high disease activity observed in 86.1% of cases. Proteinuria (93.1%), hematuria (83.7%), and leukocyturia (76.9%) were frequent findings. The mean eGFR was 77.8 ± 42.4 mL/min/1.73 m², and 37.1% of patients had renal impairment (eGFR < 60). Histologically, Class III (36.1%) and Class IV (29.2%) were most prevalent, followed by Class II (18.1%) and Class V (11.1%). Statistically significant differences were identified in albumin (p = 0.027), SLEDAI (p = 0.009), activity index (p < 0.001), and chronicity index (p = 0.001) among LN classes. Class IV had the highest activity index, indicating more severe inflammatory lesions, while Class V displayed the highest chronicity, signifying longer-standing glomerular damage. Other laboratory and demographic variables did not differ significantly (p > 0.05).
Over a five-year period, lupus nephritis at Kariadi Hospital predominantly affected young women, with high rates of anemia, proteinuria, and renal dysfunction. The significant correlation of histological activity and chronicity with LN class emphasizes their clinical utility in assessing disease severity and guiding therapeutic intensity. These findings highlight the importance of renal biopsy as a cornerstone for individualized LN management and underscore the need for early detection to prevent irreversible renal damage.
