Ultrasound localization microscopy in chronic kidney disease and its correlation with renal biopsy in IgA nephropathy

Certificate Output Instructions

For best output, select "Paper Size" as "A4" and "Margin" as "0" or "None".

To save or print to PDF, please select Print Destination > Save as PDF, enable Background Graphics under "More Settings", then click "Save".

Presented the abstract " "
(Abstract co-author(s): )

Back

E-Poster Presentation

During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.

Preparing your E-Poster

Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.

E-Poster Submission Deadline

Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.

E-Poster Format Requirements

PDF file
Layout: Portrait (vertical orientation)
One page only (Dim A4: 210 x 297mm or PPT)
E-Poster can be prepared in PowerPoint (one (1) PowerPoint slide) but must be saved and submitted as PDF file.
File Size: Maximum file size is 2 Megabytes (2 MB)
No hyperlinks, animated images, animations, and slide transitions
Language: English
Include your abstract number
E-posters can include QR codes, tables and photos

E-Poster

https://storage.unitedwebnetwork.com/files/1099/b2e6a59478c5ec9e38418370b300c564.pdf

Abstract Title *

Ultrasound localization microscopy in chronic kidney disease and its correlation with renal biopsy in IgA nephropathy

Please follow the instructions below to input your abstract title.

Abstract titles should be brief and reflect the content of the abstract.

The title will not be accepted if it exceeds 25 words.
Type in CAPITAL LETTERS.
Lowercase may be used for abbreviations only, for example, mRNA.

Co-author 1

Yuanyuan Su 847240050@qq.com University-Town Hospital of Chongqing Medical University Department of Nephrology Chongqing China *

Co-author 2

Zhiyan Gong a47332886@126.com The First Affiliated Hospital of Chongqing Medical University Department of Ultrasound Chongqing China -

Co-author 3

Co-author 4

Co-author 5

Co-author 6

Co-author 7

Co-author 8

Co-author 9

Co-author 10

Co-author 11

Co-author 12

Co-author 13

Co-author 14

Co-author 15

Introduction

Chronic kidney disease (CKD) is recognized as a major health problem, causing more than a million deaths each year worldwide. For most CKD, peripheral kidney microvascular damage can be correlated with disease progression. Ultrasound localization microscopy (ULM) is a novel non-invasive method for quantitatively assessing renal microcirculation. This study evaluates the use of ULM in CKD and its correlation with renal biopsy in IgA nephropathy.

Methods

The study comprised 33 CKD patients and 20 control subjects between June 2025 and September 2025 in the department of ultrasound of the first affiliated hospital of Chongqing medical university. All participants underwent renal biopsy. ULM was performed to measure microvascular flow quantitative characteristics the cortex area. ULM parameters were compared with eGFR. Subsequently, 21 patients with pathologically confirmed IgA nephropathy were divided into M0 and M1 groups based on the Oxford classification. ULM parameters of these two groups were compared.

Results

ULM analysis revealed that, compared to controls, CKD patients exhibited significantly lower vessel ratio, blood velocity, and vessel count (p < 0.05). These parameters were negatively correlated with eGFR (r=-0.346). In IgA nephropathy patients, vessel ratio and blood velocity in the M1 group were significantly lower than in the M0 group (p < 0.05). Vessel ratio and blood velocity were negatively correlated with mesangial cell proliferation (r=-0.427), proteinuria (r=-0.485), and endocapillary hypercellularity (r=-0.373).

Conclusion

ULM provides detailed insight into the microvascular structure and hemodynamic changes in CKD, presenting a promising tool for early diagnosis and monitoring of disease progression.

Kewords