CHALLENGES AND OUTCOMES OF ACUTE INTERMITTENT HAEMODIALYSIS IN NIGERIAN CHILDREN WITH SEVERE VIRAL HAEMORRHAGIC FEVERS

 

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CHALLENGES AND OUTCOMES OF ACUTE INTERMITTENT HAEMODIALYSIS IN NIGERIAN CHILDREN WITH SEVERE VIRAL HAEMORRHAGIC FEVERS

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Adewale
Adetunji
Adewale Adetunji tunjiwale2007@yahoo.com Irrua Specialist Teaching Hospital Paediatrics Irrua Nigeria * Ambrose Alli University Paediatrics Ekpoma Nigeria
Sylvia Olomu sylolomu@yahoo.co.uk Irrua Specialist Teaching Hospital Paediatrics Irrua Nigeria - Ambrose Alli University Paediatrics Ekpoma Nigeria
Sheila Ileli sheilaojor14@gmail.com Irrua Specialist Teaching Hospital Paediatrics Irrua Nigeria -
Lilian Akerele lillimo2001@yahoo.com Irrua Specialist Teaching Hospital Paediatrics Irrua Nigeria - Ambrose Alli University Paediatrics Ekpoma Nigeria
Chukwuemeka Ugadu stangeneral84@gmail.com Irrua Specialist Teaching Hospital Paediatrics Irrua Nigeria - Ambrose Alli University Paediatrics Ekpoma Nigeria
Christiana Ekuma oluwachristye@gmail.com Irrua Specialist Teaching Hospital Paediatrics Irrua Nigeria -
Fidel Ezeome fezeome@gmail.com Irrua Specialist Teaching Hospital Paediatrics Irrua Nigeria -
Nwamaka Ejidike dollymakas@yahoo.com Irrua Specialist Teaching Hospital Paediatrics Irrua Nigeria -
Mojeed Rafiu raphymoj2012@gmail.com Irrua Specialist Teaching Hospital Internal Medicine Irrua Nigeria - Ambrose Alli University Medicine Ekpoma Nigeria
Chukwuemeka Azubuike emeazuog@gmail.com Irrua Specialist Teaching Hospital Internal Medicine Irrua Nigeria - University of Benin Medical Physiology Benin City Nigeria
Lisa Oestereich oestereich@bnitm.de Bernhard Nocht Institute of Tropical Medicine Virology Hamburg Germany -
Till Omansen till.omansen@bnitm.de Bernhard Nocht Institute of Tropical Medicine Virology Hamburg Germany -
Stephan Gunther guenther@bni.uni-hamburg.de Bernhard Nocht Institute of Tropical Medicine Virology Hamburg Germany -
George Akpede georgeakpede@yahoo.co.uk Irrua Specialist Teaching Hospital Paediatrics Irrua Nigeria - Ambrose Alli University Paediatrics Ekpoma Nigeria
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There are very few reports on the challenges of and response to Acute Intermittent Haemodialysis (AIHD) in severe paediatric viral hemorrhagic fevers (VHFs) in lower-middle income countries (LMICs) where VHFs are prevalent. This is despite the increasing recognition of the contribution of acute kidney injury (AKI) to mortality in severe cases, including Lassa fever (LF) and yellow fever (YF). This study was aimed at reducing these knowledge gaps in paediatric VHFs with severe AKI.

We reviewed our experience with 33 children treated at Irrua Specialist Teaching Hospital between January 2018 and March 2025 who had KDIGO stage 3 AKI, 25 (76%) with LF and 8 (24%) with YF. We compared the characteristics and outcomes of dialyzed and undialyzed groups, including the number of AIHD sessions among those with LF & YF who were dialyzed. We also sought to determine the reasons for lack of access to dialysis where the procedure could not be administered. We used Chi square or Fisher’s exact test as appropriate to compare the groups, with the level of significance set at p <0.05.

Seventeen (52%) of the 33 children completed at least 1 session of AIHD and had a total of 51 sessions (range = 1-7, mean = 3) while 16 (48%) could not be dialyzed. The characteristics of the children in “dialyzed” versus “undialyzed” groups are as shown in Table I. Lack of access to dialysis among the 16 children was due to unavailability of age-appropriate consumables for AIHD/absence of facilities for automated peritoneal dialysis or inability to improvise peritoneal dialysis for fear of the  high risk of nosocomial transmission of LF (n = 7), death in the dialysis room (2 after canulation, and 1 within 25 minutes of commencement of ), and inability to stabilize the child for AIHD because of haemodynamic instability/lack of access to continuous renal replacement therapy (CRRT, n = 6). Among those who were dialyzed, the average no. of sessions was similar between Lassa and Yellow fevers; 2.9 versus 3.2 (p >0.999). The risk of death among the dialyzed versus undialyzed groups was 7/17 (41%) versus 14/16 (88%); odds ratio (95% Confidence Interval) = 0.1 (0.02, 0.59), p = 0.006.

AIHD in children with severe VHFs in LMICs could be quite challenging, but lifesaving. More effort is needed to improve on the access to dedicated paediatric dialysis facilities, including the options of CRRT and automated peritoneal dialysis

Kewords