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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
α-Klotho is a kidney-derived anti-aging protein that exerts pleiotropic effects on phosphate homeostasis, oxidative stress, and fibrosis. Reduced circulating α-Klotho levels have been associated with chronic kidney disease progression, vascular calcification, and adverse transplantation outcomes. Renal transplantation may partially restore Klotho production via the transplanted kidney; however, longitudinal data linking post-transplant Klotho recovery and cardiac remodeling remain limited. This study aimed to characterize serum α-Klotho kinetics in the early and late post-transplant periods and to examine whether early α-Klotho levels are associated with left ventricular mass index (LVMI) as a marker of cardiac remodeling.
Seventeen kidney transplant recipients (mean age 46.7 ± 12.4 years; 12 males, 5 females) were prospectively followed. Blood samples were obtained at four standardized timepoints: before transplantation (Pre), 1 week (1W), 3 months (3M), and 1 year (1Y) post-transplantation. Serum α-Klotho concentrations were measured using a quantitative sandwich ELISA (Immuno-Biological Laboratories, Japan). Echocardiographic assessment of LVMI was performed at 1 year post-transplant. Differences in α-Klotho across timepoints were analyzed by repeated-measures ANOVA with Bonferroni correction. Correlations between 3-month α-Klotho and LVMI (g/m²) were evaluated using linear regression and Spearman rank correlation. Statistical significance was set at p < 0.05.
The mean serum α-Klotho concentrations were: Pre = 326.6 pg/mL, 1W = 305.5 pg/mL, 3M = 414.9 pg/mL, and 1Y = 440.0 pg/mL. Compared with baseline, α-Klotho significantly increased at 3 months and remained elevated at 1 year (p < 0.05). Higher α-Klotho levels at 3 months were associated with lower LVMI at 1 year (β = −0.082, p = 0.055), suggesting that early Klotho restoration may have a cardioprotective effect through favorable cardiac remodeling.
Serum α-Klotho levels in kidney transplant recipients exhibit a biphasic pattern, with an early postoperative decline followed by progressive recovery within the first year. Elevated α-Klotho at 3 months post-transplant was inversely associated with LVMI at 1 year, suggesting that early restoration of Klotho may contribute to improved cardiac remodeling and reduced left ventricular hypertrophy. Serial α-Klotho monitoring could serve as a non-invasive biomarker reflecting both allograft recovery and cardiovascular health. Larger multicenter studies are warranted to validate α-Klotho as a prognostic marker in the cardio-renal continuum after kidney transplantation.
