CARDIOMETABOLIC MANAGEMENT AND PRESCRIPTION OF KIDNEY-PROTECTIVE AGENTS AMONG THAI PATIENTS WITH CKD: INSIGHTS FROM THE THAI CKD PROJECT

 

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https://storage.unitedwebnetwork.com/files/1099/c7f0d24d2363a798c51994784dbef21d.pdf
CARDIOMETABOLIC MANAGEMENT AND PRESCRIPTION OF KIDNEY-PROTECTIVE AGENTS AMONG THAI PATIENTS WITH CKD: INSIGHTS FROM THE THAI CKD PROJECT

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Kavita
Jintanapramote
Kavita Jintanapramote kavita.jint@gmail.com Bhumibol Adulyadej Hospital Medicine Bangkok Thailand *
Thatsaphan Srithongkul thatsaphan@gmail.com Mahidol University Faculty of Medicine Siriraj Hospital Medicine Bangkok Thailand -
Thananda Trakarnvanich thananda@hotmail.com Faculty of Medicine Vajira Hospital Medicine Bangkok Thailand -
Juthamash Sangsuk sjuthamash@yahoo.com Chiangkham Hospital Medicine Phayao Thailand -
Sirirat Asawamethapant gonggi11@yahoo.com Sisaket Hospital Medicine Sisaket Thailand -
Jathurong Kittrakulrat j.kittrakulrat@gmail.com Prapokklao Hospital Medicine Chanthaburi Thailand -
Tossaporn Sapsitthikul toom0668@gmail.com Samutprakan Hospital Medicine Samutprakan Thailand -
Narittaya Varothai narittaya.nga@gmail.com Phramongkutklao College of Medicine Medicine Bangkok Thailand -
Sirirat Anutrakulchai sirirt_a@kku.ac.th Khon Kaen University Medicine Khon Kaen Thailand -
Chanchana Boonyakrai pooboonyakrai@hotmail.com Taksin Hospital Medicine Bangkok Thailand -
Kajohnsak Noppakun kajohnsak.noppakun@cmu.ac.th Chiang Mai University Faculty of Medicine Medicine Chiang Mai Thailand -
Wonngarm Kittanamongkolchai wonngarm.k@chulacrc.org Chulalongkorn University Faculty of Medicine Medicine Bangkok Thailand -
Talerngsak Kanjanabuch golfnephro@hotmail.com Chulalongkorn University Faculty of Medicine Medicine Bangkok Thailand -
Vuddhidej Ophascharoensuk vuddhidej@hotmail.com Chiang Mai University Faculty of Medicine Medicine Chiang Mai Thailand -
Paweena Susantitaphong pesancerinus@hotmail.com Chulalongkorn University Faculty of Medicine Medicine Bangkok Thailand -

Cardiometabolic risk control and the use of kidney-protective treatments are central to slowing CKD progression. Current guidelines emphasize four pillars of therapy: renin–angiotensin system inhibitors (RASi), sodium–glucose cotransporter-2 inhibitors (SGLT2i), glucagon-like peptide-1 receptor agonists (GLP-1RA), and non-steroidal mineralocorticoid receptor antagonists (ns-MRA). The ns-MRA were not yet available in Thailand during the study period. This study evaluated cardiometabolic control and the uptake of kidney-protective agents among Thai CKD patients.

Baseline data from the Thai CKD Project, ongoing prospective cohort study enrolling adults with CKD stages G3–G5 (eGFR ≤60 mL/min/1.73 m²) from 41 hospitals nationwide, were analyzed among patients with CKD G3–G5 (eGFR ≤ 60 mL/min/1.73 m²). Optimal control was defined as blood pressure (BP) <130 mmHg, HbA1c <7%, and LDL-cholesterol <100 mg/dL. Medication use, including RASi, statins, SGLT2i, and GLP-1RA, was examined overall, by diabetes status, and across KDIGO G×A categories. Prescription patterns were compared between academic medical centers and tertiary care hospitals, with statistical significance defined as p < 0.05.

Among 3,344 CKD participants (mean age 69 ± 12 years; 45% female; 50% with diabetes), cardiometabolic control remained modest: BP <130 mmHg in 39%, HbA1c <7% among those with diabetes in 59%, and LDL <100 mg/dL in 64%.Use of kidney-protective agents was: RASi 42%, statins 70%, SGLT2i 14% (28% among diabetes patients), and GLP-1RA 5.6%. RASi use declined with advanced CKD stage, whereas SGLT2i and GLP-1RA were prescribed mainly in diabetic patients with preserved eGFR. Treatment disparities across KDIGO G×A staging indicated a continued underutilization of SGLT2i and GLP-1RA, especially SGLT2i in non-diabetic patients and advanced CKD (Figure 1).Figure 1. KDIGO G×A heatmaps of kidney-protective therapy in Thai CKD.  

When comparing different types of hospitals, academic medical centers prescribed more antihypertensive, lipid-lowering, and kidney-protective medications, such as SGLT2i and GLP-1RA (p < 0.001). While tertiary hospitals achieved better BP control and showed greater NSAID use (p < 0.001). (Table 1)

Cardiometabolic control among Thai patients with CKD remains suboptimal, and the use of kidney-protective therapies such as SGLT2i and GLP-1RA is limited. Academic medical centers focus on pharmacological and nephroprotective strategies, while tertiary hospitals achieve better blood pressure control. Integrating these complementary strengths and enhancing access to nephroprotective medications may improve renal and cardiovascular outcomes nationwide.

Kewords