REGIONAL DISPARITIES IN CHRONIC KIDNEY DISEASE ACROSS THAILAND: INSIGHTS FROM THE THAI CKD PROJECT

 

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https://storage.unitedwebnetwork.com/files/1099/64389d2d9519ae5c0074afd833ae568e.pdf
REGIONAL DISPARITIES IN CHRONIC KIDNEY DISEASE ACROSS THAILAND: INSIGHTS FROM THE THAI CKD PROJECT

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Kavita
Jintanapramote
Kavita Jintanapramote kavita.jint@gmail.com Bhumibol Adulyadej Hospital Medicine Bangkok Thailand *
Thatsaphan Srithongkul thatsaphan@gmail.com Mahidol University Faculty of Medicine Siriraj Hospital Medicine Bangkok Thailand -
Thananda Trakarnvanich thananda@hotmail.com Faculty of Medicine Vajira Hospital Medicine Bangkok Thailand -
Juthamash Sangsuk sjuthamash@yahoo.com Chiangkham Hospital Medicine Phayao Thailand -
Sirirat Asawamethapant gonggi11@yahoo.com Sisaket Hospital Medicine Sisaket Thailand -
Jathurong Kittrakulrat j.kittrakulrat@gmail.com Prapokklao Hospital Medicine Chanthaburi Thailand -
Tossaporn Sapsitthikul toom0668@gmail.com Samutprakan Hospital Medicine Samutprakan Thailand -
Narittaya Varothai narittaya.nga@gmail.com Phramongkutklao College of Medicine Medicine Bangkok Thailand -
Sirirat Anutrakulchai sirirt_a@kku.ac.th Khon Kaen University Medicine Khon Kaen Thailand -
Chanchana Boonyakrai pooboonyakrai@hotmail.com Taksin Hospital Medicine Bangkok Thailand -
Kajohnsak Noppakun kajohnsak.noppakun@cmu.ac.th Chiang Mai University Faculty of Medicine Medicine Chiang Mai Thailand -
Phanupong Phutrakool phanupong.p@chula.ac.th Chulalongkorn University Faculty of Medicine Medicine Bangkok Thailand -
Talerngsak Kanjanabuch golfnephro@hotmail.com Chulalongkorn University Faculty of Medicine Medicine Bangkok Thailand -
Vuddhidej Ophascharoensuk vuddhidej@hotmail.com Chiang Mai University Faculty of Medicine Medicine Chiang Mai Thailand -
Paweena Susantitaphong pesancerinus@hotmail.com Chulalongkorn University Faculty of Medicine Medicine Bangkok Thailand -

Chronic kidney disease (CKD) constitutes a significant public health issue in Thailand. However, our understanding of etiological variation and the potential to develop regionally individualized preventive or management strategies remains limited. This study aimed to establish patient demographics, underlying causes, and geographic variations in CKD features and complications across regions of Thailand.

The Thai CKD Project is an ongoing prospective cohort study enrolling adults with CKD stages G3–G5 (eGFR ≤60 mL/min/1.73 m²) from 41 hospitals nationwide. Participants are being followed longitudinally for at least two years to assess disease progression and outcomes. The present analysis reports baseline demographic, clinical, and laboratory characteristics across six regions. CKD etiologies were classified as diabetes, hypertension, glomerulonephritis, or other causes. Complications included anemia (Hb <10 g/dL), metabolic acidosis (HCO₃ <22 mmol/L), hyperphosphatemia (>4.5 mg/dL), hyperkalemia (>5.5 mmol/L), and secondary hyperparathyroidism (PTH >65 pg/mL). Regional differences were evaluated using χ² testing.

Among 3,344 participants (mean age 69 ± 12 years; 45% female), CKD stages were distributed as G3a 20%, G3b 33%, G4 37%, and G5 10%. CKD etiologies: Diabetes and hypertension were predominant, but their distributions varied markedly by region (p < 0.001). Diabetes-related CKD was the most common etiology across several regions, particularly in the Northeast (43%), East (41%), West (41%), and South (39%). Hypertension-related CKD predominated in the North (41%). The highest proportions of CKD of unknown etiology (CKDu) were observed in the Central (34%) and West (25%) regions. Glomerulonephritis accounted for only a small proportion in all regions (1–5%). Overall, diabetes and hypertension remained the leading causes of chronic kidney disease nationwide. (Figure 1)

Figure 1. Distribution of CKD causes by region

Complications: Overall prevalence was 22% for anemia, 22% for metabolic acidosis, 6% for hyperphosphatemia, 1.4% for hyperkalemia, and 58% for secondary hyperparathyroidism. Regional variation was statistically significant for anemia, metabolic acidosis, hyperphosphatemia, and secondary hyperparathyroidism (all p < 0.001), and modest for hyperkalemia (p = 0.013). The most pronounced disparity was observed in metabolic acidosis across regions. (Figure 2)

The etiology and complication patterns of CKD in Thailand reveal significant regional variations. The high incidence of unknown causes in Central and West areas, along with significant differences in metabolic complications, highlights the necessity for additional research and implementation of region-specific clinical and public health strategies to effectively reduce the nationwide burden of CKD.

Kewords