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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Cardiovascular-kidney-metabolic (CKM) syndrome is a dynamic process characterized by complex pathophysiological interplays among metabolic dysregulation, chronic kidney disease, and cardiovascular dysfunction and contributes substantially to global disease burden. Evidence regarding the independent and joint impact of social determinants of health (SDOH) and lifestyle on longitudinal CKM trajectories remains limited. This study aims to elucidate the effects of these factors on CKM progression to inform early risk stratification and personalized management strategies.
A total of 48,446 participants with CKM Stage 1 from the UK Biobank were included. Participants were categorized into favourable, intermediate, and unfavourable SDOH groups based on tertiles of a composite score of baseline indicators. They were also stratified into healthy or unhealthy lifestyle groups based on a score derived from diet, sleep, physical activity, smoking, and alcohol status. Stages of CKM syndrome were determined based on biochemical criteria and International Classification of Disease (ICD)-10 codes. A multi-state model was used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for the impact of SDOH and lifestyle on CKM progression across the dynamic stages: Stage 1, Stage 2, Stage 4, and death.
During the follow-up, 6,865 (14.17%) Stage 1 participants progressed to Stage 2, ultimately resulting in 3,451 cases of Stage 4 and 1,943 deaths. Compared to the favourable SDOH group, the unfavourable SDOH group was associated with significantly elevated risks of CKM progression across major progression transitions, including Stage 1 to Stage 2 (HR[95% CI]:1.38 [1.30-1.46]), Stage 1 to Stage 4 (HR[95% CI]:1.12 [1.02-1.24]), Stage 2 to Stage 4 (HR[95% CI]:1.35 [1.14-1.61]), and Stage 4 to death (HR[95% CI]:1.68 [1.36-2.08]). Unhealthy lifestyle group was also associated with significantly higher risks than healthy lifestyle group for Stage 1 to Stage 2 (HR[95% CI]:1.17 [1.12-1.23]) and Stage 4 to death (HR[95% CI]:1.21 [1.02-1.43]). Most notably, compared to participants with favourable SDOH and healthy lifestyle, those with both unfavourable SDOH and unhealthy lifestyle had significantly higher risks of CKM progression across all stages, except for the transition from Stage 2 to death.
Our findings demonstrate that SDOH and lifestyle are collectively associated with the progression of CKM syndrome. The most vulnerable group is characterized by the joint presence of adverse SDOH and unhealthy lifestyle. This underscores the urgency of implementing integrated management strategies, as advocated in initiatives by the American Heart Association(AHA) and the International Society of Nephrology(ISN), to identify and protect vulnerable populations affected by adverse SDOH and unhealthy lifestyle.
