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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
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E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
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While there is abundance of literature on the comorbidities associated with pediatric chronic kidney disease (CKD), limited literature exists regarding Health-Related Quality Of Life (HRQOL) assessment in these children, especially from a Lower-Middle Income Country (LMIC) perspective.
Children aged 2-18 years with CKD stages 2-5 attending the pediatric nephrology clinic of a tertiary-care center in South India from June 2024 to June 2025 were assessed for HRQOL using the validated Pediatric Quality of Life Questionnaires (PedsQL 4.0 GCS and PedsQL 3.0 ESRD Module). Parent-proxy questionnaire was administered to all parents while child self-report questionnaire was reported by children ≥ 8 years. The PedsQL 4.0 GCS questionnaire was administered to both the cases and controls, while the PedsQL 3.0 ESRD Module was reported only by those with CKD.
One hundred and twenty-five children with CKD, and equal number of age and gender-matched controls, with median (IQR) age of 11 (8-14) years were enrolled. Congenital anomalies of the kidney and urinary tract (CAKUT) was the most common (57.6%) etiology of CKD. Among the enrolled patients, 77 (61.6%) children were in advanced CKD (stages 3b-5) and 15 (12%) were on dialysis. The net parent-proxy HRQOL score by PedsQL 4.0 GCS scale was 76 ± 21 in the cases and 95 ± 3 in the controls (p<0.001). When the cases were categorized as early (stages 2-3a) and advanced (stages 3b-5) CKD, patients with advanced CKD had a much lower score of 77 [54-88], when compared to that of early CKD which is 92 [84-96] (p<0.001). As depicted in Fig.1, school absence and physical activity limitation were the domains maximally affected. When patients with early and advanced CKD were assessed by PedsQL 3.0 ESRD Module, similar scores were observed - 76 [64-85] in advanced vs 88 [79-93] in early CKD, p<0.001; however, multiple domains were severely affected with worsening CKD (Fig.2). School absence, rickets, young age at CKD onset and advanced CKD were the major risk factors for poor HRQOL.
Fig 1. Box and whisker plots depicting the distribution of health-related quality of life PedsQL GCS 4.0 parent-proxy score in controls (orange), early (green) and advanced [stages 3b-5] CKD (purple)
Fig 2. Box and whisker plots depicting the distribution of health-related quality of life scores across the various domains of PedsQL ESRD Module 3.0 parent-proxy scale between early (blue) and advanced (pink) CKD
CKD significantly impacts HRQOL in children, with restriction of physical activity and school absence being the most important domains affected. Addressing these aspects is likely to improve their overall quality of life. Hence, attention must be given to these facets as well during the child’s routine visit to the hospital to ensure holistic care.
