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Preparing your E-Poster
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E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
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Abstract titles should be brief and reflect the content of the abstract.
Neonates born preterm have low nephron endowment, thereby predisposing them to chronic kidney disease. Limited data exists regarding the kidney outcomes at corrected age of 1 yr in preterm neonates born before 34 weeks of gestation.
Consecutive preterm neonates born before 34 weeks of gestation in a tertiary-care hospital in South India from Jan 2023 to July 2024 and followed up in the neuro-developmental clinic were evaluated for kidney outcomes at corrected age of 1 year. Anthropometric parameters were recorded and blood pressure was measured by standard protocols and classified as per the American Academy of Pediatrics 2017 Hypertension guidelines. Proteinuria was quantified by spot urine protein-creatinine ratio (UpUc) and considered abnormal if UpUc was > 0.5 mg/mg. Serum creatinine was measured by modified Jaffe method traceable to Isotope Dilution Mass Spectrometry. Estimated glomerular filtration rate (eGFR) was calculated by modified Schwartz formula and considered abnormal if eGFR was < 60 mL/1.73 m2 per min. Kidney size was measured by ultrasonography using a curvilinear 5 MHz frequency transducer, and total kidney volume (TKV) was determined using the ellipsoid formula. TKV < 25.7 cm3 was considered abnormal.
During the 1.5 year enrolment period, 124 preterm neonates (56% boys and 30% small-for-gestational-age) born at 31 ± 2 weeks were enrolled at a corrected age of 12 ± 0.3 months. Hypertension was noted in 6 (4.8%) children. The median (IQR) UpUc was 0.3 (0.2, 0.4) mg/mg. Proteinuria was found in 27 (21.8%) children, however, none had nephrotic-range proteinuria. eGFR < 90 and 60 ml/1.73 m2 per min were observed in 20 (16.1%) and 8 (6.5%) participants, respectively. The median (IQR) right and left kidney lengths were 56 (52-60) and 56 (52.5-59.5) cm, with the TKV being 38.5 (34.1-45.1) cm3. Adverse kidney outcome (hypertension, UpUc>0.5, eGFR <60, or TKV <25.7) was noted in 41 (33.1%) children (Fig.1). These kidney outcomes were not statistically different between children born appropriate vs small for gestational age.
Despite being asymptomatic, one in three neonates born before 34 weeks of gestation developed adverse kidney outcomes by 1 year of corrected age. This high proportion of kidney abnormalities warrants a proactive assessment of kidney status in preterm neonates during their routine follow-up for growth and neuro-developmental monitoring.
