ETIOLOGY AND CARDIAC OUTCOMES OF CHILDREN WITH RESISTANT HYPERTENSION

 

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ETIOLOGY AND CARDIAC OUTCOMES OF CHILDREN WITH RESISTANT HYPERTENSION

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Sudarsan
Krishnasamy
Sudarsan Krishnasamy sudarsanjipmer@gmail.com JIPMER Pediatrics Puducherry India *
Anju Mariam Jacob anjujacob100@gmail.com JIPMER Pediatrics Puducherry India -
Shanmugasundaram Kalatheeswaran nkshanmugamsundaram@gmail.com JIPMER Pediatrics Puducherry India -
Longjam Rida Devi longjamridadevi@gmail.com JIPMER Pediatrics Puducherry India -
Avinash Anantharaj avinboxer@gmail.com JIPMER Cardiology Puducherry India -
Bobbity Deepthi deepu.reddy222@gmail.com JIPMER Pediatrics Puducherry India -
Sriram Krishnamurthy drsriramk@yahoo.com JIPMER Pediatrics Puducherry India -
 
 
 
 
 
 
 
 

Resistant hypertension (RH) is defined as blood pressure that is uncontrolled despite the use of 3 antihypertensive medications of different classes at maximally tolerated doses. While RH is increasingly reported in adults, literature on RH in pediatric patients is scarce.

We did a cross-sectional study on consecutive children < 18 years of age on 3 or more antihypertensive medications for at least 3 months and attending a tertiary-care hospital in South India from July 2023 to July 2025. Investigations done for etiological evaluation were retrieved from medical records. All enrolled children were subjected to one-time cross-sectional evaluation by echocardiography for the following parameters- left ventricular hypertrophy (LVH), left ventricular ejection fraction (LVEF), global longitudinal strain (GLS) by speckle-tracking echo, trans-mitral and pulmonary venous doppler, and tissue doppler imaging. These cardiac parameters were classified as normal or abnormal based on standard pediatric references.

During the 2 year enrolment period, 54 children (61% boys) with mean age of 11 ± 3.7 years and on 3 or more BP drugs for the preceding 14 [9-33] months were enrolled. Renal causes accounted for 92% cases, with glomerular disorders, renovascular hypertension, and congenital anomalies of the kidney and urinary tract (CAKUT) contributing to 28%, 24%, and 22%, respectively. Endocrine causes such as Phaeochromocytoma, cardiac causes like Takayasu aorto-arteritis, and miscellaneous causes including Prader Willi Syndrome with obstructive sleep apnea contributed to the remaining cases (Fig.1). Twelve (22%) patients were on 5 or more drugs, with calcium channel blockers and beta blockers being the most commonly employed agents. Diuretics were used in only 7% of cases. LVH (borderline and definite combined) was observed in 70% of patients. Systolic (LVEF and GLS) and diastolic (doppler parameters) dysfunction were observed in 50% and 65% patients, respectively.

Renal parenchymal and renovascular disorders were the predominant causes of resistant hypertension in children in this study. An alarming proportion of RH patients have significant structural and/or functional cardiac abnormalities warranting strict BP control and regular cardiac assessments to prevent major adverse cardiovascular events in adulthood.

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