U-SHAPED ASSOCIATION BETWEEN BODY MASS INDEX AND MORTALITY IN TAIWANESE DIABETES PATIENTS: A NATIONWIDE COHORT STUDY

 

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https://storage.unitedwebnetwork.com/files/1099/858cc7893a6d9cc2f2e70f4b8e6e8a09.pdf
U-SHAPED ASSOCIATION BETWEEN BODY MASS INDEX AND MORTALITY IN TAIWANESE DIABETES PATIENTS: A NATIONWIDE COHORT STUDY

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Ko-Lin
Kuo
Kuan-Cheng Kuo alexkuo.md14@nycu.edu.tw National Yang Ming Chiao Tung University Department of Medicine, College of Medicine Taipei City Taiwan -
Chih-Cheng Hsu cch@nhri.edu.tw National Health Research Institutes Institute of Population Health Sciences Miaoli County Taiwan -
Ko-Lin Kuo kolinkuo8@gmail.com Taipei Tzu Chi Hospital Division of Nephrology New Taipei City Taiwan *
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Previous studies have reported inconsistent associations between body mass index (BMI) and mortality in patients with diabetes, ranging from protective effects of being overweight to increased risks with both low and high BMI. Large-scale, long-term evidence in Asian populations—where body composition differs from Western populations—remains limited.

Using Taiwan’s diabetes care program from 2002 to 2015, we identified 440,942 adults with diabetes and followed them until December 31, 2023. Participants were categorized into six BMI groups: <20, 20–23, 24–26, 27–34, 35–46, and ≥47 kg/m², comprising 17,262, 116,207, 141,889, 139,636, 25,702, and 246 individuals, respectively. The mean age was 60.4 years, and 49.4 % were female.

Over a median follow-up of 13.8 years, all-cause mortality rates per 1,000 person-years were 55.6, 40.5, 35.0, 32.3, 29.3, and 31.1 across the BMI groups, respectively. In multivariable Cox regression adjusting for age, sex, smoking, alcohol consumption, blood pressure, glycated hemoglobin, total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein, serum albumin, uric acid, microalbumin, glomerular filtration rate, the adjusted hazard ratios (95 % CIs) for mortality were 1.95 (1.89–2.00), 1.13 (1.12–1.14), 1.00 (reference), 0.99 (0.98–0.99), 1.22 (1.19–1.24), and 1.52 (1.24–1.85).

This large cohort revealed a U-shaped association between BMI and all-cause mortality in diabetes. Both underweight and markedly obese patients exhibited elevated mortality risk. These findings suggest a non-linear association between BMI and long-term mortality risk in patients with diabetes, emphasizing the need for further research to determine causal mechanisms and optimal BMI thresholds.

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