Relationship between Indoxyl Sulfate and Layer-Specific Left Ventricular Strain and Cardiovascular Hospitalization in Patients Undergoing Maintenance Hemodialysis

Certificate Output Instructions

For best output, select "Paper Size" as "A4" and "Margin" as "0" or "None".

To save or print to PDF, please select Print Destination > Save as PDF, enable Background Graphics under "More Settings", then click "Save".

Presented the abstract " "
(Abstract co-author(s): )

Back

E-Poster Presentation

During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.

Preparing your E-Poster

Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.

E-Poster Submission Deadline

Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.

E-Poster Format Requirements

PDF file
Layout: Portrait (vertical orientation)
One page only (Dim A4: 210 x 297mm or PPT)
E-Poster can be prepared in PowerPoint (one (1) PowerPoint slide) but must be saved and submitted as PDF file.
File Size: Maximum file size is 2 Megabytes (2 MB)
No hyperlinks, animated images, animations, and slide transitions
Language: English
Include your abstract number
E-posters can include QR codes, tables and photos

E-Poster

Abstract Title *

Relationship between Indoxyl Sulfate and Layer-Specific Left Ventricular Strain and Cardiovascular Hospitalization in Patients Undergoing Maintenance Hemodialysis

Please follow the instructions below to input your abstract title.

Abstract titles should be brief and reflect the content of the abstract.

The title will not be accepted if it exceeds 25 words.
Type in CAPITAL LETTERS.
Lowercase may be used for abbreviations only, for example, mRNA.

Co-author 1

Kun Xiao xiaokun1227@126.com The First Affiliated Hospital of Dalian Medical University Department of Nephrology Dalian China -

Co-author 2

Xu Zhang zhangxu906@126.com The First Affiliated Hospital of Dalian Medical University Department of Nephrology Dalian China -

Co-author 3

Nan Wang wangn0712@126.com The First Affiliated Hospital of Dalian Medical University Department of Nephrology Dalian China -

Co-author 4

Hongli Lin hllin@dmu.edu.cn The First Affiliated Hospital of Dalian Medical University Department of Nephrology Dalian China *

Co-author 5

Co-author 6

Co-author 7

Co-author 8

Co-author 9

Co-author 10

Co-author 11

Co-author 12

Co-author 13

Co-author 14

Co-author 15

Introduction

Indoxyl sulfate (IS), a protein-bound uremic toxin, has been linked to increased mortality from cardiovascular disease in patients receiving maintenance hemodialysis.The purpose of this research was to evaluate the connection between serum IS concentration and layer-specific systolic strain of the left ventricular myocardium, as well as cardiovascular disease-related hospital admissions in MHD patients.

Methods

A prospective cohort study was carried out by researchers, involving 86 patients undergoing maintenance hemodialysis at the First Affiliated Hospital of Dalian Medical University from January 1, 2022, to May 31, 2022, with follow-up continuing until May 31, 2024. Two-dimensional speckle tracking imaging (2D-STI) was used to assess baseline and two-year echocardiographic parameters, such as endomyocardial, middle-layer, and epimyocardial strains, to evaluate layer-specific global longitudinal strain (GLS). Systematic records were kept of cardiovascular hospitalization events, and logistic regression analysis was used to identify risk factors associated with hospitalization for cardiovascular disease.

Results

The patients were classified into two groups based on the median serum indoxyl sulfate level: one with low indoxyl sulfate (< 41.85 mg/L) and another with high indoxyl sulfate (≥ 41.85 mg/L). Throughout two years, the GLS of the epimyocardial, middle-layer, and endomyocardial layers (GLSendo, GLSmid, GLSepi) showed a more significant decrease in the high indoxyl sulfate group compared to the low indoxyl sulfate group. Over the course of two years, there were 18 cases of hospitalization related to cardiovascular disease. The analysis using multivariate logistic regression showed that indoxyl sulfate was an independent factor in increasing the risk of hospitalizations due to cardiovascular disease in MHD patients (OR = 1.05, 95% CI 1.00–1.10; P < 0.05).

Conclusion

The findings suggest that over two years, layer-specific GLS significantly worsened in the high indoxyl sulfate group, and elevated IS levels are a strong predictor of hospitalization for cardiovascular disease. Further extensive, prospective research is required to validate these results.

Kewords