Prevalence and associated factors of chronic kidney disease-associated pruritus in China: A multicenter, cross-sectional study

 

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https://storage.unitedwebnetwork.com/files/1099/248e9c88ef1c51ed018beac11b0b55ee.pdf
Prevalence and associated factors of chronic kidney disease-associated pruritus in China: A multicenter, cross-sectional study

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Xi
Yao
Xi Yao amyyao616@163.com Kidney Disease Center The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou China * Key Laboratory of Kidney Disease Prevention and Control Technology Zhejiang Province Hangzhou China
Ping Zhang 13588016833@163.com Kidney Disease Center The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou China - Key Laboratory of Kidney Disease Prevention and Control Technology Zhejiang Province Hangzhou China
Xiaoying Du 1820724747@qq.com Kidney Disease Center The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou China - Key Laboratory of Kidney Disease Prevention and Control Technology Zhejiang Province Hangzhou China
Jianghua Chen chenjianghua@zju.edu.cn Kidney Disease Center The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou China - Key Laboratory of Kidney Disease Prevention and Control Technology Zhejiang Province Hangzhou China
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As far as we know, there has been no epidemiological reports on chronic kidney disease (CKD)-associated pruritus (CKD-aP) with large sample size in China in recent years. We aimed to investigate the prevalence and related factors of CKD-aP in China.

This study included data on 9,896 patients with uremia in 30 provincial-level administrative divisions in mainland China between May 2022 and December 2022.  The questionnaire involved basic patient information, clinical and laboratory test results. 

The prevalence of CKD-aP in Chinese uremic patients was 61.6%. The prevalence of moderate to severe pruritus was 16.4%, and the prevalence of severe pruritus was 3.5%. The prevalence of pruritus, moderate to severe pruritus and severe pruritus in hemodialysis (HD) patients was 61.1%, 16.6% and 3.5%, respectively. Smoking history, diabetic nephropathy, cardiovascular and cerebrovascular diseases, skin diseases, dialysis vintage, eosinophil count, serum total calcium, and serum phosphorus were risk factors for CKD-aP.

Our study reported the prevalence of CKD-aP and its risk factors in the Chinese uremic population, which may contribute to the prevention of CKD-aP.

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