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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Tubulointerstitial nephritis (TIN) is characterized by kidney dysfunction and minimal urinary abnormalities. TIN may also be associated with glucosuria. However, the clinical characteristics of patients with positive urinary glucose levels have not been investigated sufficiently. This study aimed to elucidate the clinical characteristics of TIN patients with glucosuria.
This retrospective, observational study was conducted at two institutions (Yamanashi University Hospital and Yamanashi Central Hospital). The study included patients diagnosed with TIN based on renal biopsy between 2015 and 2024. Patients with concomitant glomerulonephritis or a history of kidney transplantation were excluded. Glycosuria was defined as follows: (1) patients without overt diabetes mellitus (DM) who showed urinary glucose ≥1+ on urinalysis at the time of renal biopsy (prior to treatment), or (2) patients with DM who were not taking sodium glucose co-transporter 2 inhibitors and had simultaneous plasma glucose levels <120 mg/dL with urinary glucose (≥1+). The study population was divided into two groups according to the presence or absence of glycosuria. Patient characteristics and clinical parameters were compared between the two groups.
A total of 59 patients were diagnosed with TIN, of whom 17 (28.8%) showed urinary glucose positivity. The glycosuria-positive group had a higher incidence of idiopathic and drug-induced conditions (p = 0.03) and a lower proportion of systemic diseases such as Sjögren’s syndrome, sarcoidosis, immunoglobulin G 4-related kidney disease, and vasculitis. The glycosuria-positive group also demonstrated lower serum uric acid and phosphate levels (both p < 0.05) and a higher prevalence of hematuria, as well as higher urinary N-acetyl-beta-D-glycosaminidase levels and urinary protein-to-creatinine ratios (both p < 0.01). Notably, age, sex, serum creatinine levels, and estimated glomerular filtration rate (eGFR) did not differ significantly between the two groups. Overall, steroid therapy was administered to 46 patients (78%). Among patients who received steroid treatment, changes in eGFR from baseline to treatment initiation did not differ significantly between the groups; however, the glycosuria-positive group showed significantly greater improvement in eGFR at 1, 3, and 6 months after treatment initiation (all p < 0.05). Moreover, the rates of partial and complete remission at 6 months were significantly higher in the glycosuria-positive group than in the glycosuria-negative group (84.6% vs. 46.1%, p = 0.04).
The occurrence of glycosuria differs according to the etiology of TIN, suggesting that the clinical characteristics of TIN varies depending on the presence or absence of glycosuria.
