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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Sjögren's syndrome (SjS) is a chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands, including the lacrimal and salivary glands. SjS can be accompanied by renal lesions, including tubulointerstitial lesions and glomerulonephritis. Herein, we report the case of an elderly male with SjS complicated by focal segmental glomerulosclerosis (FSGS).
A 67-year-old male presented with a one-month history of edema and weight gain of >10 kg. The patient was diagnosed with nephrotic syndrome, as evidenced by severe proteinuria (urine protein-to-creatinine ratio, 8.2 g/gCr) and hypoalbuminemia (1.7 g/dL). The patient’s renal function was preserved. Serological test results were positive for antinuclear antibodies, rheumatoid factor, and anti-SS-A autoantibodies. Complement levels were normal, and tests for anti-dsDNA antibodies, monoclonal proteins, and cryoglobulins were negative. Despite minimal sicca symptoms, a lip biopsy confirmed SjS diagnosis. A renal biopsy confirmed the diagnosis of FSGS, with immunofluorescence showing no significant immune deposits and electron microscopy revealing diffuse effacement of the podocyte foot processes.
The initial treatment with corticosteroids and cyclosporine was ineffective. Nephrotic syndrome was refractory, prompting the addition of rituximab and low-density lipoprotein apheresis four weeks later. This combination therapy led to a gradual decrease in proteinuria and an increase in serum albumin levels. The patient achieved partial remission, which persisted after discharge.
Herein, we describe a rare case of refractory nephrotic syndrome due to FSGS in a patient with SjS, who was successfully managed using multidisciplinary treatment. This case suggests that a multitarget therapeutic strategy addressing the potential pathologies of both SjS and FSGS may be effective in such challenging cases.
