50-YEAR TREND OF THE INCIDENCE OF CHRONIC DIALYSIS PATIENTS IN THE OKINAWA DIALYSIS STUDY (OKIDS) REGISTRY (1971-2020)

 

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https://storage.unitedwebnetwork.com/files/1099/b478c435233b33887b9c4d3db84200fe.pdf
50-YEAR TREND OF THE INCIDENCE OF CHRONIC DIALYSIS PATIENTS IN THE OKINAWA DIALYSIS STUDY (OKIDS) REGISTRY (1971-2020)

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KUNITOSHI
ISEKI
KUNITOSHI ISEKI chihokun_ohra@yahoo.co.jp Nakamura Clinic Clinical research support center NAHA Japan *
TAKUHIRO MOROMIZATO tmoromizato@gmail.com Okinawa Prefectural Nanbu Medical Center and Children's Medical Center Division of Nephrology NAHA Japan -
CHIHO ISEKI chihokun2000@ybb.ne.jp Nakamura Clinic Clinical research support center NAHA Japan -
AKIRA HIGA akirahiga@icloud.com Shuri Jokamachi Clinic Nephrology and dialysis division NAHA Japan -
KENTARO KOHAGURA kohagura@med.u-ryukyu.ac.jp Ryukyu University Hospital Dialysis Unit GINOWAN Japan -
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We have been studying a community-based dialysis registry in Okinawa (Okinawa Dialysis Study, OKIDS), Japan, since the beginning of dialysis therapy in 1971. We reported the increasing trend of dialysis patients up to 2000 (Kidney Int 2002; 61: 668-675). However, it has not yet studied in the recent 20 years (2001 to 2020). Okinawa prefecture is located southernmost part of Japan and consists of isolated islands. Therefore, most dialysis patients remain within the district.

Table 1. Demographics of the chronic dialysis patients in Okinawa, Japan (1971-2020).We registered all chronic dialysis patients and excluded those who had insufficient data (N=8), age<18 years old at start dialysis (N=93), died within one month after starting dialysis and non-residents such as travelers and foreigners. Data were collected with the full collaboration from all dialysis facilities. A total of 15,698 patients were studied (Table 1).

 

Primary renal disease (PRD) was grouped into six such as chronic glomerulonephritis (CGN), diabetes mellitus (DM), nephrosclerosis (NScl), autosomal dominant polycystic kidney disease (PKD), systemic lupus nephritis (SLE), and others. Population and age-adjusted incidence were calculated. The standardized incidence ratio (SIR) was calculated as the reference for the incidence of 2020. Joinpoint regression analysis was applied to examine the trend of SIR and used the join point regression program, version 5.3.0.0. Population of Okinawa increased from 0.95 million (1970) to 1.47 million (2020). Number of dialysis facility has increased from 49 (2000) to 74 (2020). Data are expressed as mean (SD). All analyses were done using the STATA. A P-value less than 0.05 was considered as significant.

Figure 1. Percentage of chronic glomerulonephriti (CGN) by age at start dialysis.Figure 2. Changes ib standardized incidence ratio (SIR) in women and men.Results: In 1971-1980, the percentage of the main PRD was CGN (79.2%), DM (6.0%) and NScl (6.5%), but they were CGN (23.4%), DM (45.4%), and NScl (12.5%) in 2011-2020. In particular, the mean age at start dialysis has changed clearly in CGN (Figure 1).

In total, the mean age at start dialysis increased from 38.7 years (1971-1980) to 67.2 years (2011-2020). They were 64.1 years in women and 60.9 years in men. SIR has declined since 1994 in women and 1999 in men (Figure 2). In women, the annual percent change (APC) was 8.77% (1974-1994, P<0.05) and -1.24% (1994-2020, not significant). In men, APC was 33.3% (1974-1978, P<0.05), 4.29% (1978-1999, P<0.05), and -0.49% (1999-2020, P<0.05).

                      

Incidence of dialysis patients has declined since the 4th decade as CGN has decreased largely. Factors related to the trend are considered as; firstly, kidney disease screening using dipstick urine test was started for school-age children in the early 1970s. In 1983, mandatory kidney disease screening for adults aged ≥40 yr was started. A specific nationwide health check-up and guidance system (Tokutei-Kenshin) was initiated in April 2008. Further reduction of dialysis patients due to DM and NScl is also expected by early detection of CKD, lifestyle modification, and proper use of drugs. 


This abstrat was presented at the WCN2026 in Yokohama, Japan. I also declare that re-submitting the abstract is permitted by the organizers of the original meeting.

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