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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Inflammatory bowel disease (IBD) typically presents with gastrointestinal symptoms such as bloody stool and diarrhea. However, patients with IBD are also at risk for renal dysfunction due to frequent occurrences of prerenal acute kidney injury (AKI) and drug-induced nephrotoxicity. Despite this, the long-term renal prognosis of patients with IBD has not been well characterized. Furthermore, it remains unclear whether the progression of renal function differs between ulcerative colitis (UC) and Crohn’s disease (CD). In this study, we evaluated long-term changes in renal function by comparing the slope of the estimated glomerular filtration rate (eGFR) between patients with UC and those with CD, using the eGFR slope as an indicator of time-dependent renal function decline.
This study was conducted as a single-center retrospective observational study. Patients aged ≥18 years who first visited the IBD Center of Yokohama City University Medical Center between January 2007 and May 2023 and were diagnosed with UC or CD were included. Patients with suspected AKI at their initial visit, baseline eGFR < 60 mL/min/1.73 m², or a history of renal replacement therapy were excluded. Longitudinal eGFR data over a period of up to 10 years were used to calculate individual annual eGFR slopes (mL/min/1.73 m²/year). The rates of eGFR decline were compared between UC and CD, and univariate and multivariate analyses were conducted to identify factors associated with accelerated renal function decline.
A total of 1,573 patients (UC: 1,174, CD: 399) were included in the analysis. The mean eGFR slope was significantly steeper in the UC group (−1.23 mL/min/1.73 m²/year) than in the CD group (−0.80 mL/min/1.73 m²/year), with a between-group difference of −0.43 (p < 0.001). Higher serum total cholesterol and albumin levels were associated with a slower rate of eGFR decline, whereas hypertension and corticosteroid use were associated with a more rapid decline in renal function. In contrast, the use of 5-aminosalicylic acid and azathioprine tended to attenuate the decline in eGFR.
Patients with UC experienced a significantly faster decline in renal function than patients with CD. Furthermore, since nutritional status and medications have long been associated with renal function in IBD patients, appropriate disease control, optimization of nutritional status, and careful management of comorbidities such as hypertension may play an important role in preserving renal function and improving long-term renal outcomes.
