DIGITAL COGNITIVE BEHAVIORAL THERAPY FOR HYPERKALEMIA IN MAINTENANCE HEMODIALYSIS PATIENTS: A PROSPECTIVE, SINGLE-CENTER, RANDOMIZED CONTROLLED TRIAL

 

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DIGITAL COGNITIVE BEHAVIORAL THERAPY FOR HYPERKALEMIA IN MAINTENANCE HEMODIALYSIS PATIENTS: A PROSPECTIVE, SINGLE-CENTER, RANDOMIZED CONTROLLED TRIAL

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Lin
Hongli
Zeng Xin 1365591783@qq.com The First Affiliated Hospital of Dalian Medical University Nephrology Dalian China -
Lin Hongli linhongli@vip.163.com The First Affiliated Hospital of Dalian Medical University Nephrology Dalian China *
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Hyperkalemia represents a serious complication in maintenance hemodialysis (MHD) patients, significantly increasing risks of all-cause mortality, cardiovascular events, and hospitalization. Current management is complicated by comorbidities, medication-related potassium elevation, and complex dietary restrictions, creating an urgent need for innovative strategies. Digital cognitive behavioral therapy (dCBT) offers a promising approach through behavior modification but its efficacy for hyperkalemia management remains unestablished.

This single-center randomized controlled trial enrolled 73 MHD patients with recurrent hyperkalemia. Participants were allocated to receive either 8 weeks of smartphone-based dCBT plus standard care (n=37) or standard care alone (n=36), followed by 4 weeks of observation. The primary outcome was change in serum potassium from baseline to week 8. Secondary outcomes included serum phosphate, quality of life (KDQOL-36), self-efficacy (GSES), and medication adherence (MMAS-8), .assessed at baseline, week 4, week 8 (end of intervention), and week 12 (follow-up). Analysis employed repeated-measures ANOVA with appropriate post-hoc testing.

图1。参与者流程图

The dCBT group demonstrated significantly greater reduction in serum potassium compared to controls (group-by-time interaction P=0.002). Serum potassium decreased from 5.73±0.45 mmol/L to 5.02±0.47 mmol/L at week 8 in the dCBT group, remaining stable at follow-up (5.05±0.51 mmol/L), with significantly lower levels versus control (5.29±0.52 mmol/L) at week 8 (P=0.010). The dCBT group also showed substantial improvements in physical health-related quality of life, self-efficacy, and medication adherence. No significant between-group differences were observed in serum phosphate levels.

图2。dCBT和对照组血清钾水平随着时间的推移而变化。图3。dCBT和对照组血清磷酸盐水平随着时间的推移而变化。图4。dCBT和对照组中PCS水平随着时间的推移而变化。图5。dCBT和对照组MCS水平随着时间的推移而变化。图6。dCBT和对照组KDCS随着时间的推移而变化。图7。dCBT和对照组GSES水平随着时间的推移而变化。

Digital cognitive behavioral therapy effectively reduces serum potassium levels and improves key patient-reported outcomes in MHD patients with hyperkalemia. The intervention demonstrates sustained effects and represents a comprehensive approach to hyperkalemia management that addresses both physiological and behavioral aspects of care. These findings support the integration of dCBT into standard renal care protocols for improved hyperkalemia management.

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