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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Circulating CD34-positive cells comprise hematopoietic stem and progenitor cells and reflect hematopoietic function and marrow reserve. Lower circulating CD34-positive cell counts have been linked to hematopoietic stem-cell aging and to higher risks of infection, cardiovascular events, and mortality. Chronic kidney disease (CKD) also increases mortality; however, the association between circulating CD34-positive cell counts and CKD has not been fully investigated. This study aimed to clarify the relationship between circulating CD34-positive cell count and clinical characteristics in CKD patients.
We enrolled 195 outpatients with CKD stages G3–G5 (median age, 76 years; 66.3% men). Patients with active infection, collagen disease, or acute kidney injury were excluded. Circulating CD34⁺CD45^dim cells were enumerated by flow cytometry. Multivariable linear regression was conducted to evaluate associations between circulating CD34-positive cell counts and clinical variables, including peripheral blood parameters (hematologic indices and T-cell subsets) and CKD-related clinical features.
The median circulating CD34-positive cell count was 0.68/μL. Lower CD34-positive cell counts were significantly associated with lower white blood cell counts (p<0.001), platelet counts (p<0.001), lymphocyte counts (p<0.001), and CD4⁺ T-cell counts (p<0.001). In addition, older age (p<0.001), lower eGFR (p=0.007), and higher intact parathyroid hormone levels (p=0.006) were associated with lower CD34-positive cell counts. Anemia showed no association with CD34-positive cell count.
In CKD patients, circulating CD34-positive cell counts were associated with hematologic indicators hematologic parameters and decreased kidney function. These findings suggest that renal dysfunction, in addition to aging, may contribute to diminished hematopoietic function and marrow reserve.
