LARGER KIDNEY SIZE IN HYPERTENSIVE MALES IN A GENERAL POPULATION: AN MRI-BASED STUDY

 

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https://storage.unitedwebnetwork.com/files/1099/6e88084d92df9f5e7b441bc3bb1af517.pdf
LARGER KIDNEY SIZE IN HYPERTENSIVE MALES IN A GENERAL POPULATION: AN MRI-BASED STUDY

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Sylvia
Stracke
Jonas Wille jonas.wille@med.uni-greifswald.de University Medicine Greifswald Nephrology, Internal Medicine A Greifswald Germany -
Thomas Dabers thomas.dabers@med.uni-greifswald.de University Medicine Greifswald Nephrology, Internal Medicine A Greifswald Germany -
Tilman Schmidt tilman.schmidt@med.uni-greifswald.de University Medicine Greifswald Nephrology, Internal Medicine A Greifswald Germany -
Mohamad Baqi Zaidan mohamadbaqi.zaidan@med.uni-greifswald.de University Medicine Greifswald Dermatology Greifswald Germany -
Robert Wolf robert.wolf@med.uni-greifswald.de University Medicine Greifswald Nephrology, Internal Medicine A Greifswald Germany -
Philipp Töpfer philipp.toepfer@med.uni-greifswald.de University Medicine Greifswald Nephrology, Internal Medicine A Greifswald Germany -
Birger Mensel mensel@staff.uni-marburg.de Philipps University Marburg Radiology Marburg Germany -
Roberto Lorbeer roberto.lorbeer@med.uni-muechen.de University Hospital LMU Radiology München Germany -
Henry Voelzke voelzke@uni-greifswald.de University Medicine Greifswald Community Medicine SHIP-Clinical-Epidemiological Research Greifswald Germany -
Till Ittermann till.ittermann@med.uni-greifswald.de University Medicine Greifswald Community Medicine SHIP-Clinical-Epidemiological Research Greifswald Germany -
Sylvia Stracke sylvia.stracke@med.uni-greifswald.de University Medicine Greifswald Nephrology, Internal Medicine A Greifswald Germany *
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Arterial hypertension (AHT) is a major cardio-reno-vascular risk factor (CVRF) that can lead to kidney injury. It is known that AHT as well as diabetes or smoking can lead to glomerular hyperfiltration and hypertrophy, and later to nephron loss and chronic kidney disease (CKD). In our study, we analysed whether AHT is associated with sex/age specific changes in kidney size.

We included 1916 participants (983 females) between 21 and 81 years without kidney disease for measurement of left and right renal volume (RV) using magnetic resonance imaging from the Study of Health in Pomerania (SHIP-TREND-0). We defined two subgroups of AHT, namely AHT1: systolic BP > 140 mmHg or diastolic BP > 90 mmHg or presence of AHT in the standardised interview or intake of antihypertensive medication, AHT2: intake of antihypertensive medication). We analysed AHT1 and AHT2 separately. Linear regression models adjusted for confounding factors were performed for both subgroups of AHT and kidney size.

AHT1 was associated with a higher RV in males, particularly for the right RV (β = 6.18; 95 % CI 2.02; 10.32; p < 0.05). In contrast, we found no significant association of AHT1 with RV in females. AHT2 was only associated with the right RV in males (β = 4.71; 95 % CI 0.25; 9.16; p < 0.05). Both AHT1 and AHT2 were significant associated with RV up to an age of around 55 years. Age-dependent associations were stronger in males than in females for nearly all ages.

Associations of both AHT1 and AHT2 with RV were stronger in males than in females. The accumulation of CVRF in middle-aged males possibly explained by gendered behaviour may account for the sex differences seen for RV in participants with AHT in our population.

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