Correlation Between Parathyroid Hormone and Body Mass Index in Chronic Hemodialysis Patients: A Cross-Sectional Study in Mexico

 

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Correlation Between Parathyroid Hormone and Body Mass Index in Chronic Hemodialysis Patients: A Cross-Sectional Study in Mexico

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Sara Isabel
Estrada Intriago
Sara Isabel Estrada Intriago dra.eintriago@gmail.com Mexican Institute of Social Security Nephrology Nephrology Mexico *
Luis Rafael Alvarez Velazquez alvarezlr_65@gmail.com Mexican Institute of Social Security Nephrology Nephrology Mexico -
 
 
 
 
 
 
 
 
 
 
 
 
 

Secondary hyperparathyroidism (SHPT) is a common complication in patients with end-stage kidney disease (ESKD) on hemodialysis (HD). Obesity has been associated with altered mineral metabolism and elevated PTH levels. However, data on the relationship between body mass index (BMI) and PTH in Mexican HD patients is lacking.

A prospective, cross-sectional, observational and analytical study was conducted at a tertiary referral center in Ciudad Obregón, Mexico, from June to October 2023. We included 188 adult patients undergoing HD for ≥3 months. Anthropometric measurements (weight and height) and serum iPTH levels were obtained. Correlation between iPTH and BMI was analyzed using Pearson and Spearman correlation tests. A p-value ≤0.05 was considered statistically significant.

Correlation between BMI and iPTH Scatter plot


BMI disctribution by categoriesAmong 188 patients (mean age 57.5 ± 13.9 years; 51.1% female), mean BMI was 27.01 ± 5.99 kg/m². The distribution of BMI was: 40.4% normal weight, 31.4% overweight, 25% obese, and 3.2% underweight. Mean iPTH was 580.89 ± 576.77 pg/mL. A weak but statistically significant positive correlation was found between BMI and iPTH (Pearson r = 0.126, p = 0.043; Spearman rho = 0.143, p = 0.025). No significant differences in iPTH levels were observed when comparing BMI groups (p = 0.211).

Our findings indicate a weak positive correlation between BMI and iPTH levels in chronic HD patients. Although statistically significant, this association may lack clinical relevance. Further studies incorporating additional confounders (e.g., diet, physical activity, vitamin D status) and serial PTH measurements are needed to elucidate this relationship and guide SHPT management strategies in obese HD patients.

Kewords