Back
For best output, select "Paper Size" as "A4" and "Margin" as "0" or "None".
To save or print to PDF, please select Print Destination > Save as PDF, enable Background Graphics under "More Settings", then click "Save".
During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Peripheral arterial stiffness (PAS) is prevalent in chronic kidney disease (CKD) and contributes to cardiovascular risk. We investigated whether circulating osteoprotegerin (OPG), a cytokine linked to vascular calcification, is associated with PAS assessed by brachial-ankle pulse wave velocity (baPWV) in CKD.
In a cross-sectional cohort of 200 adults with CKD, left/right baPWV, clinical characteristics, and serum OPG were measured. The serum OPG levels were measured using a commercial enzyme-linked immunosorbent assay kit. Patients with left or right baPWV >18.0 m/s were classified in the PAS group, whereas those with baPWV ≤ 18.0 m/s were assigned to the control group.
Out of 200 non-dialysis CKD patients, 86 (43%) were in PAS groups. Compared with the control group, the rates of diabetes mellitus (DM, P = 0.023), hypertension (P = 0.010), old age (P < 0.001), systolic blood pressures (P < 0.001), spot urine protein-to-creatinine ratio (UPCR, P = 0.004), as well as the serum levels of OPG (P < 0.001), were higher, while estimated glomerular filtration rate (eGFR, P = 0.003) were lower in the PAS group. In fully adjusted models, OPG (per 1 pg/mL) remained independently associated with PAS (odds ratio [OR]: 1.008, 95% confidence interval [CI]: 1.002–1.015, P = 0.010), along with older age (OR: 1.069, 95% CI: 1.027–1.112, P = 0.001) and DM (OR: 2.745, 95% CI: 1.282–5.876, P = 0.009). Additionally, a positive association was found between the serum logarithmically transformed OPG (log-OPG) levels and either the left or right baPWV (all P < 0.001, respectively) in non-dialysis CKD patients according to the Spearman's rank correlation coefficient test. OPG discriminated PAS with an area under the curve of 0.721 (95% CI: 0.651–0.792, P < 0.0001).
In CKD, higher circulating OPG is independently associated with the presence of PAS and correlates with greater baPWV. OPG shows fair diagnostic performance for identifying PAS and may serve as a vascular risk marker in CKD.
