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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Aortic stiffness is common in patients receiving maintenance hemodialysis (HD) and contributes to adverse cardiovascular outcomes. We investigated whether circulating endothelin-1 (ET-1), a potent vasoconstrictor and endothelial mediator, is associated with aortic stiffness measured by carotid–femoral pulse wave velocity (cfPWV) in HD patients.
Blood samples were obtained from 134 chronic HD patients who had received standard 4-hour dialysis 3 times per week. Patients with cfPWV values of >10 m/s were classified in the aortic stiffness group, whereas those with cfPWV values of ≤ 10 m/s were assigned to the control group. Serum ET-1 levels were quantified using commercially available enzyme-linked immunosorbent assays.
Fifty HD patients (37.3%) who belonged to the aortic stiffness group were generally older (P = 0.014), higher incidence of diabetes mellitus (P = 0.025), hypertension (P = 0.001), higher systolic blood pressures (SBP, P < 0.001), diastolic blood pressure (P < 0.001), higher serum glucose (P = 0.033), and ET-1 levels (P < 0.001) than the control group. In multivariable logistic regression, ET-1 (per 0.01 pmoL/L) (odds ratio [OR]: 1.066, 95% confidence interval [CI]: 1.035–1.099, P < 0.001) was independently associated with aortic stiffness after adjusting for clinical cofounders. In stepwise linear regression, logarithmically transformed ET-1 (log-ET-1, β = 0.451, P < 0.001), SBP (β = 0.362, P < 0.001), and age (β = 0.187, P = 0.004) was positively associated with cfPWV values in patients with chronic HD. ET-1 discriminated aortic stiffness with an area under the curve of 0.790 (95% CI: 0.716–0.864, P < 0.001).
Among HD patients, serum ET-1 levels are found to be positively correlated with cfPWV values, and higher circulating ET-1 levels are independently associated with aortic stiffness, beyond age and blood pressure.
