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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
In peritoneal dialysis (PD), peritoneal membrane dysfunction is primarily attributed to angiogenesis. However, the integrity of vascular endothelial cells can also affect peritoneal permeability. The glycocalyx is a bioactive, gel-like layer that plays a role in maintaining a negative charge, regulating coagulation, and controlling microvascular permeability. We previously reported that the digestion of hyaluronan in the glomerular glycocalyx results in proteinuria (Physiol Rep. 2021). Our recent study demonstrated that the degradation of hyaluronan in the glycocalyx of peritoneal endothelial cells induces protein leakage and can accelerate the development of encapsulating peritoneal sclerosis (EPS) (Sci Rep 2024). It has been reported that glycocalyx (hyaluronan) in glomerular capillary endothelial cells is reduced in diabetic nephropathy (JASN 2010). At the start of PD, morphologic changes to the peritoneum, such as increased thickness of the submesothelial compact zone and capillary density, are evident in diabetic patients (Perit Dial Int. 2013). In this study, we investigated whether hyaluronan expression in the peritoneal capillary glycocalyx is altered in diabetic patients at the start of PD.
We studied the expression of hyaluronan and heparan sulfate in blood vessels in a total of 73 peritoneal membrane tissue samples from patients with chronic renal failure at the time of peritoneal dialysis catheter insertion. We compared the expression levels between 33 diabetic patients (DM group) and 40 patients without diabetes (non-DM group). We visualized expression of peritoneal hyaluronan and heparan sulfate (HS) that is core protein of glycocalyx using biotin-labeled human hyaluronan-binding protein (HABP) and HS. We also measured the thickness of the submesothelial compact zone in the peritoneal membrane.
Expression of hyaluronan in vascular endothelial cells was significantly lower in the DM group than in the non-DM group (P < 0.0001). However, there was no difference in heparan sulfate expression. The peritoneal submesothelial compact zone was significantly thicker in the DM group (P < 0.0001).
This study suggests that altered endothelial cell glycocalyx may be involved in peritoneal transport in patients with DM.
