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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Diabetic kidney disease (DKD) stands as a formidable global health challenge, recognized as the predominant cause of end-stage renal disease (ESRD). Traditionally, DKD is characterized by a constellation of clinical features, including persistent albuminuria, a gradual decline in glomerular filtration rate (GFR), and distinct histo-pathological changes such as glomerular basement membrane thickening, mesangial expansion, and nodular glomerulosclerosis. However, clinical practice has increasingly recognized that a substantial proportion of individuals with diabetes mellitus (DM) develop kidney pathologies unrelated to their diabetic state. These conditions are collectively termed Non-Diabetic Kidney Disease (NDKD). The reported prevalence of NDKD in diabetic patients undergoing renal biopsy exhibits considerable variability in medical literature, ranging from approximately 10% to over 80%, underscoring its significant clinical relevance. The accurate differentiation between NDKD and pure DKD is paramount for effective patient management. Treatment strategies, prognostic implications, and the potential for disease reversibility diverge significantly between these two entities. This study aims to characterize the comprehensive spectrum of biopsy-proven kidney diseases, particularly NDKD (isolated or superimposed on DKD), in a cohort of diabetic patients.
We retrospectively analyzed renal biopsy data from 90 diabetic patients (mean age 46.72 ± 11.23 years; 71.1% male; 96.66% T2DM). Patient characteristics, diabetes duration, comorbidities (85.55% hypertension, 60% diabetic retinopathy), initial clinical presentations (e.g., nephrotic syndrome in 41, rapidly progressive renal failure in 33), and laboratory findings were assessed.
Baseline Characteristics of the Study Cohort (N=90)
Biopsy results revealed a significant burden of NDKD: 25.55% had NDKD superimposed on DKD, and 31.11% had pure NDKD, totaling 56.66% with a non-diabetic renal pathology. Pure DKD accounted for 43.33%. NDKD was frequently observed in patients with short diabetes duration (e.g., de novo) and atypical presentations such as rapidly progressive renal failure, nephritic syndrome, or significant hematuria. Common NDKD types included acute/chronic tubulointerstitial nephritis (ATIN/ATI/CTIN) (9 pure, 11 superimposed) and infection-related glomerulonephritis (IRGN) (4 pure, 3 superimposed), alongside IgA nephropathy and membranous nephropathy.
This study highlights the substantial prevalence and diverse spectrum of NDKD in diabetic patients undergoing renal biopsy. The findings underscore the critical role of biopsy for accurate diagnosis and tailored management. Clinical suspicion for NDKD should be high in diabetic patients with atypical features, irrespective of diabetes duration or traditional diabetic complications, to prevent irreversible kidney damage.
