ASSOCIATION BETWEEN DYSPHAGIA AND CKD PREVALENCE: A CROSS-SECTIONAL STUDY

 

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https://storage.unitedwebnetwork.com/files/1288/f05eee39f97ea0efca38139b87b91600.pdf
ASSOCIATION BETWEEN DYSPHAGIA AND CKD PREVALENCE: A CROSS-SECTIONAL STUDY

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Masahiro
Egawa
Masahiro Egawa korofuji0211@gmail.com Izumo Medical Life Cooperative Izumo-shimin Hospital Division of Nephrology Izumo Japan *
Kosuke Matsui matsui_med@ybb.ne.jp Izumo Medical Life Cooperative Izumo-shimin Hospital Division of Nephrology Izumo Japan -
Ryuichi Yoshimura yoshimura.ryuichi.ci@teikyo-u.ac.jp Teikyo University Chiba Medical Center Division of Nephrology, Department of Internal Medicine Ichihara Japan -
Kaori Yoshikane sansainotani@yahoo.co.jp Izumo Medical Life Cooperative Izumo-shimin Hospital Division of Nephrology Izumo Japan -
Takafumi Ito itou.takafumi.ax@teikyo-u.ac.jp Teikyo University Chiba Medical Center Division of Nephrology, Department of Internal Medicine Ichihara Japan -
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With the global increase in the aging population, chronic kidney disease (CKD) has become a growing public health concern. Dysphagia is common among older adults and can lead to malnutrition and frailty; however, its relationship with CKD remains unclear. This study aimed to clarify whether a severity-dependent association exists between dysphagia and the prevalence of CKD.

We conducted a retrospective cross-sectional study involving 520 patients aged ≥65 years who were admitted to Izumo Medical Life Cooperative Izumo-shimin Hospital between April 2022 and May 2023. Swallowing function was evaluated using the modified water swallowing test (MWST) and graded on a 5-point scale. Dysphagia was defined as a score of 1–3. CKD was defined as an estimated glomerular filtration rate (eGFR) ≤60 mL/min/1.73 m². Logistic regression analyses were performed to assess the association between dysphagia and CKD prevalence, adjusting for clinically relevant variables including age, sex, comorbidities, and nutritional status.

The prevalence of CKD was 38.0%, 57.9%, and 62.2% among patients with normal, nearly normal, and dysphagic swallowing function, respectively. In multivariable-adjusted analyses, dysphagia was significantly associated with a higher prevalence of CKD (adjusted odds ratio [aOR] 2.51; 95% confidence interval [CI], 1.01–6.20). Moreover, a severity-dependent trend was observed: compared with patients without dysphagia, the aORs for CKD were 1.76 (95% CI, 0.92–3.36) in those with almost normal swallowing, 2.43 (95% CI, 0.96–6.16) in mild dysphagia, and 3.24 (95% CI, 0.42–25.0) in moderate-to-severe dysphagia (p for trend = 0.044).

Dysphagia was independently associated with the prevalence of CKD in older adults, and this association appeared to be severity dependent. 

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