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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Polyamines are small polycationic molecules involved in cellular processes such as proliferation, immune modulation and autophagy. They have been implicated in chronic disease development; however, their association with long-term kidney transplantation outcomes remains unknown. We investigated if urinary polyamines are longitudinally associated with death-censored graft failure, all-cause mortality and new onset diabetes after transplantation (NODAT) in kidney transplant recipients.
588 kidney transplant recipients with a stable functioning kidney allograft were included in this longitudinal cohort study. Clinical parameters, dietary intake, laboratory data, and 24-hour urine samples were collected during inclusion. Polyamines were measured using high-performance liquid chromatography (HPLC) in 24-hour urine. Cox proportional hazards regression analysis and multi-state modelling were performed to study the longitudinal association between polyamine excretion and long-term outcomes.
During a median follow-up of 8.2(IQR, 4.7-8.9) years, 97 (16%) KTR developed graft failure and 190 (32%) died. In fully adjusted models, higher urinary N1-acetylspermidine (HR, 0.64 [95% confidence interval, 0.49-0.84]; p <0.01) and N8-acetylspermidine (0.65 [0.46-0.9]; p <0.05) excretion were associated with a lower risk of graft failure. Higher urinary N-acetylputrescine (0.69 [0.54-0.89]; p <0.01), N1-acetylspermidine (0.69 [0.58-0.82]; p <0.001), N8-acetylspermidine (0.58 [0.48-0.71]; p< 0.001) and spermidine (0.81 [0.67-0.98]; p <0.05) excretion were associated with lower all-cause mortality. Multi-state analyses revealed that urinary N-acetylputrescine (0.30 [0.13-0.67]; p = 0.004), N¹-acetylspermidine (0.46 [0.24-0.88]; p = 0.02) and N8-acetylspermidine (0.42 [0.22-0.82]; p = 0.01) were negatively associated with mortality following graft failure. No significant associations were observed between polyamines and incident NODAT.
Urinary polyamines, specifically N8-acetylspermidine are inversely associated with mortality risk before and after graft failure. These findings provide evidence that polyamine metabolism may play an important role in post-transplant longevity and resilience
