Impact of Connection Method and Dialysis Modality on Touch Contamination-Related Peritonitis in Peritoneal Dialysis: A 9-Year Single-Center Retrospective Study from Japan

 

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https://storage.unitedwebnetwork.com/files/1288/76ec1e3eaf2d77f016e46e137edf22ae.pdf
Impact of Connection Method and Dialysis Modality on Touch Contamination-Related Peritonitis in Peritoneal Dialysis: A 9-Year Single-Center Retrospective Study from Japan

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Kenji
Ito
Kenji Ito kito@fukuoka-u.ac.jp Faculty of Medicine, Fukuoka University Division of Nephrology and Rheumatology Fukuoka Japan *
Kazuhiro Tada ktada@fukuoka-u.ac.jp Faculty of Medicine, Fukuoka University Division of Nephrology and Rheumatology Fukuoka Japan -
Sho Shimamoto schwarze.katze.41@gmail.com Faculty of Medicine, Fukuoka University Division of Nephrology and Rheumatology Fukuoka Japan -
Koji Takahashi takahashi_k@fukuoka-u.ac.jp Faculty of Medicine, Fukuoka University Division of Nephrology and Rheumatology Fukuoka Japan -
Maho Watanabe m.watanabe.gv@cis.fukuoka-u.ac.jp Faculty of Medicine, Fukuoka University Division of Nephrology and Rheumatology Fukuoka Japan -
Katsuhisa Miyake kmiyake@fukuoka-u.ac.jp Faculty of Medicine, Fukuoka University Division of Nephrology and Rheumatology Fukuoka Japan -
Naoko Himuro uekin@fukuoka-u.ac.jp Faculty of Medicine, Fukuoka University Division of Nephrology and Rheumatology Fukuoka Japan -
Kosuke Masutani kmasutani@fukuoka-u.ac.jp Faculty of Medicine, Fukuoka University Division of Nephrology and Rheumatology Fukuoka Japan -
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Peritoneal dialysis (PD)-related peritonitis is a critical complication that can lead to deterioration of peritoneal function, catheter removal, transition to hemodialysis, encapsulating peritoneal sclerosis, and even death. Prevention is therefore of paramount importance. The International Society for Peritoneal Dialysis recommends a target incidence of PD-related peritonitis of less than 0.5 episodes per patient-year. In Japan, the reported incidence ranges from 0.21 to 0.24 episodes per patient-year, and further reduction is considered desirable. This study aimed to identify factors associated with PD-related peritonitis at our institution.

We reviewed 119 PD outpatients (84 males; mean age: 60.1 ± 15.7 years) treated at our center between January 2016 and May 2025. Associations between patient background and the occurrence of peritonitis were analyzed retrospectively.

A total of 70 peritonitis episodes occurred in 47 patients during the observation period, with an overall incidence of 0.231 episodes per patient-year. Catheter removal was required in 22 patients (31.4%), and one patient (1.4%) died. Excluding 10 episodes with clearly identifiable causes (e.g., postoperative complications, tunnel infections, or intra-abdominal sources), the remaining 60 episodes in 41 patients were presumed to be caused by touch contamination during catheter handling and were classified as touch contamination-related peritonitis for further analysis. Comparison between patients with and without touch contamination-related peritonitis revealed that manual connections were significantly more frequent in the peritonitis group (P = 0.01). In multivariate logistic regression analysis, manual connection remained an independent risk factor (odds ratio: 4.52; 95% confidence interval: 1.05–19.41; P = 0.04). When stratifying peritonitis incidence by connection method (manual vs. ultraviolet light [UV] vs. thermal bonding) and modality (APD vs. CAPD), the combination of APD with the UV-type automated connection device manufactured by Vantive showed the lowest incidence (0.095 episodes per patient-year). Additionally, patients without touch contamination-related peritonitis tended to have fewer daily connection events (P for trend = 0.07).

Automated catheter connection methods were associated with a reduced risk of touch contamination-related peritonitis. In particular, the combination of APD system and UV-type connection system demonstrated the greatest preventive effect. The APD system “Kaguya”, introduced in Japan in 2018, enables direct internal connection of dialysate bags and circuits, thereby reducing the number of daily connection procedures—a factor potentially contributing to a lower infection rate.The content described in this abstract was presented at the International Society for Peritoneal Dialysis (ISPD) 2025.

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