Clinical Considerations and Prognostic Evaluation in Super-Elderly Patients Initiating Hemodialysis

 

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Clinical Considerations and Prognostic Evaluation in Super-Elderly Patients Initiating Hemodialysis

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Yuri
Tonouchi
Yuri Tonouchi yur1t0n0uch1@shinshu-u.ac.jp Shinshu University School of Medicine Department of Nephrology Matsumoto Japan *
Makoto Harada tokomadaraha724@gmail.com Shinshu University School of Medicine Department of Nephrology Matsumoto Japan -
Yuki Nakayama nakayama.y12@gmail.com Shinshu University School of Medicine Department of Nephrology Matsumoto Japan -
Takahiko Nobuoka sirokatta51a@yahoo.co.jp Shinshu University School of Medicine Department of Nephrology Matsumoto Japan -
Koji Hashimoto khashi@shinshu-u.ac.jp Shinshu University School of Medicine Department of Nephrology Matsumoto Japan -
Yuji Kamijo yujibeat@shinshu-u.ac.jp Shinshu University School of Medicine Department of Nephrology Matsumoto Japan -
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With population aging accelerating in developed countries, clinicians increasingly encounter end-stage kidney disease (ESKD) in super-elderly patients. In Japan, where the proportion of elderly dialysis patients is particularly high, initiation of renal replacement therapy (RRT) in patients aged ≥90 years is not uncommon. However, detailed reports on the clinical course and prognosis of super-elderly patients initiating hemodialysis remain scarce. This study aimed to comprehensively evaluate the clinical course and prognosis of patients aged ≥90 years who initiated hemodialysis and to identify key management considerations.

We conducted a retrospective observational analysis of patients aged ≥90 years who developed ESKD due to chronic kidney disease and initiated hemodialysis at our institution between January 2019 and March 2025.

During the study period, 211 patients were initiated on hemodialysis at our institution, among whom 4 patients were aged ≥90 years. The mean age was 92.7 years, with a male-to-female ratio of 3:1. All patients were functionally independent in terms of basic activities of daily living (ADL) before dialysis initiation, with performance status scores ranging from 1 to 2. Vascular access comprised three native arteriovenous fistulas and one cuffed catheter. All patients had been followed regularly at the nephrology outpatient clinic of our hospital, and hemodialysis was initiated during hospitalization. The mean duration of hospital stay was 35.5 days. During hospitalization, all patients developed bacterial infections such as urinary tract infections or aspiration pneumonia, which responded well to antimicrobial therapy. No adverse events such as dialysis disequilibrium syndrome, significant intradialytic hypotension, or early vascular access complications were observed. One patient was discharged home, while three were transferred to rehabilitation facilities.

The findings of this study suggest that initiation of hemodialysis in super-elderly patients aged ≥90 years can be performed safely. Patients with a long-term history of nephrology outpatient follow-up and preserved performance status may have a relatively favorable prognosis. However, the development of bacterial infections during hospitalization resulted in prolonged hospital stays and subsequent transfer to rehabilitation facilities due to deterioration in ADL. Therefore, careful risk assessment and preventive strategies for infections are critically important in this patient population.

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