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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and severe hypersensitivity reaction characterized by rash, fever, internal organ involvement. Symptoms may persist even after withdrawal of the causative drug. Abnormal immune responses to drugs and herpesvirus reactivation are intricately involved in DRESS. Renal involvement occurs in about 30% of cases, but histopathological descriptions are limited. Most biopsy-proven cases show acute interstitial nephritis. We report a case of carbamazepine-induced DRESS complicated by granulomatous interstitial nephritis with perivascular involvement.
A 67-year-old Japanese woman developed trigeminal neuralgia and started carbamazepine. Eight weeks later, she presented with a widespread pruritic rash, eosinophilia, and elevated liver enzymes (day 0). All medications were discontinued, but the rash persisted. Hepatic dysfunction resolved by day 30, but renal function declined (SCr 3.9 mg/dL) with ongoing eosinophilia. CT showed bilateral renal enlargement and splenomegaly. The patient was transferred to our hospital on day 41 after her SCr increased to 6.5 mg/dL, eosinophils to 1,700/μL. Urinalysis showed no proteinuria or hematuria. HLA genotyping revealed HLA-A*31:01, a known risk allele for severe cutaneous adverse reactions. This case met the RegiSCAR criteria for DRESS (score 5) with widespread drug eruption, organ dysfunction, and eosinophilia.Renal biopsy on day 45 revealed diffuse lymphocytic infiltration with eosinophils and granulomatous lesions around arcuate and interlobular arteries, consistent with granulomatous interstitial nephritis. Neither serological nor histological analyses demonstrated HHV-6 reactivation. Prednisolone (30 mg/day) improved renal function, although moderate renal dysfunction persisted.
This case illustrates a rare manifestation of DRESS-associated kidney injury, characterized by perivascular granulomatous interstitial nephritis. Persistent interstitial inflammation and associated lymphangiogenesis may contribute to granuloma formation.
In this case, renal function did not fully recover despite corticosteroid therapy, and the patient progressed to chronic kidney disease. Delayed intervention for ongoing inflammation in DRESS may adversely affect renal prognosis.
