LONG-TERM MANAGEMENT OF PEDIATRIC KIDNEY TRANSPLANT RECIPIENTS

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LONG-TERM MANAGEMENT OF PEDIATRIC KIDNEY TRANSPLANT RECIPIENTS

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Co-author 1

Bassam Saeed bmsaeed2000@yahoo.com Farah association for Child with Kidney Disease Pediatric Nephrology Damascus Syrian Arab Republic *

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Introduction

Pediatric kidney transplant recipients are distinguished from adult recipients by the need for many decades of graft function, the potential effect of CKD on neurodevelopment, and the changing immune environment of a developing human.

Methods

The entire life of an individual who receives a transplant as a child is colored by their status as a transplant recipient. Not only must these young recipients negotiate all of the usual challenges of emerging adulthood (transition from school to work, romantic relationships, achieving independence from parents), but they must learn to manage a life-threatening medical condition independently.

Results

All pediatric transplant recipients must pass through this high-risk period. Factors contributing to the high graft failure rates in this period include poor adherence to treatment, potentially exacerbated by the transfer of care from pediatric- to adult-oriented care providers, and perhaps an increased potency of the immune response. We describe the characteristics of pediatric kidney transplant recipients, particularly those factors that may influence their care throughout their lives. We also discuss the risks associated with the transition from pediatric- to adult-oriented management and provide some suggestions to optimize the transition to adult-oriented transplant management and long-term outcomes.

Conclusion

Regardless of the age at transplantation, graft failure rates are higher during adolescence and young adulthood than at any other age.

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