ASSESSMENT AND STRATIFICATION OF SYMPTOMS IN CHRONIC KIDNEY DISEASE PATIENTS ON HEMODIALYSIS USING THE ESAS TOOL

 

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ASSESSMENT AND STRATIFICATION OF SYMPTOMS IN CHRONIC KIDNEY DISEASE PATIENTS ON HEMODIALYSIS USING THE ESAS TOOL

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Christine
Zomer Dal Molin
Ana Julia Weber anajuwbr@gmail.com Federal University of Santa Catarina Medical Sciences Araranguá Brazil -
Yuri Farias Lima yurifarias10297@gmail.com Federal University of Santa Catarina Medical Sciences Araranguá Brazil -
Matheus Rodrigues Pereira Mendes mathrodrpm@gmail.com Federal University of Santa Catarina Medical Sciences Araranguá Brazil -
Guilherme Ferreira Leite Santos guilhermefsantos0909@gmail.com Federal University of Santa Catarina Medical Sciences Araranguá Brazil -
Helena Meurer Heidemann helena_mh12@hotmail.com Federal University of Santa Catarina Medical Sciences Araranguá Brazil -
João Victor Silveira Macedo jvictor.smacedo@gmail.com Federal University of Santa Catarina Medical Sciences Araranguá Brazil -
Pâmela Larissa Delonzek delonzekpamela@gmail.com Federal University of Santa Catarina Medical Sciences Araranguá Brazil -
Ana Clara Mendes Cascaes anaclaracascaes13@gmail.com Federal University of Santa Catarina Medical Sciences Araranguá Brazil -
Vinícius Kenji Koura vinikoura@hotmail.com Federal University of Santa Catarina Medical Sciences Araranguá Brazil -
Christine Zomer Dal Molin christinezdm@hotmail.com Federal University of Santa Catarina Medical Sciences Araranguá Brazil *
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End-stage Chronic Kidney Disease (CKD) on hemodialysis (HD) imposes a high burden of physical and psychological symptoms on patients, such as: fatigue, pain, pruritus, sleep disturbances, anxiety, and depression. This study proposes the use of the Edmonton Symptom Assessment System (ESAS) tool to assess and stratify the intensity of these symptoms. It also aims to evaluate the functional status of patients using the Rapid Assessment of Physical Activity (RAPA), correlating the results of both tools with each other and with sociodemographic and laboratory variables.

A descriptive, quantitative, cross-sectional study was conducted at the hemodialysis service of Hospital Regional de Araranguá, SC, Brazil. Bedside interviews were performed to collect clinical/sociodemographic data and apply the ESAS and RAPA instruments. ESAS symptoms were classified as mild (0-3), moderate (4-6), or severe (7-10). Medical records were consulted for laboratory parameters. The population was 78 patients; exclusions included non-participation and lack of updated lab exams. Data analysis was conducted using Jamovi. Besides descriptive analysis, Mann-Whitney, Student's t-test, Fisher's exact test, and bivariate/multivariate linear regression models were used. p<0.05 was adopted as statistically significant.

Results of 65 patients were included (41M, 24F; mean age 55.3 years). The mean ESAS score was 30 (range 0–90), reflecting global symptom burden. Using ESAS (0-3 mild, 4-6 moderate, 7-10 severe), the most frequent severe symptoms were anxiety (n=25) and fatigue (n=21). Significant gender differences occurred for depression (p=0.022) and anxiety (p<0.001), with median anxiety 3 (mild) for males and 7.5 (severe) for females. Per RAPA, 34 patients reported light weekly activities; 21 reported never/rarely exercising. Additionally, 63 denied strength and 57 denied flexibility activities. Lower exercise levels are associated with worse appetite (p=0.003 RAPA 1, p=0.039 RAPA 4) and worse well-being (p=0.002). Low education also correlated with less exercise (p=0.002). In multivariate regression, higher PTH values are associated with longer total dialysis time (p=0.041; sample mean 883 days), possibly CKD-MBD, (Time in days = [-2.364 + 0.138·Urea + 0.810·Creatinine - 0.325·Phosphorus + 0.006·PTH]^2). Other variables (urea, creatinine, phosphorus) were included based on bivariate relevance (p<0.20) and biological plausibility.


Sample Profile

ESAS Scale ResultsRapa ScaleQuantitatite Continuous DataLinear Regression

ESAS application demonstrated efficacy in assessing and stratifying symptoms in hemodialysis patients. A higher prevalence of psychiatric symptoms (anxiety, depression) in women was noted. Low levels of physical activity were identified, correlating with a higher symptomatic burden. Although the instruments identified these associations, the score stratification method may have limited detecting other correlations. It is concluded that ESAS application enables the recognition of individuals with greater physical/emotional distress, guiding individualized interventions and contributing to comprehensive patient care.

Kewords