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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
IgA nephropathy (IgAN) is the most common primary glomerular disease. It is reported that histological findings and the degree of proteinuria correlate with renal prognosis. Further, the degree of proteinuria correlates with histological findings in IgAN. However, most of these studies have excluded cases with minimal proteinuria, and there are few data regarding histological findings in IgAN with minimal proteinuria. Furthermore, recent reports indicate that renal prognosis in IgAN with minimal proteinuria is not necessarily favorable. We examined the histological and clinical characteristics of patients presenting with proteinuria <0.3 g/gCr at the time of renal biopsy at our institution.
Forty-five patients with IgAN who underwent renal biopsy at our institution were divided into two groups: Group 1 (urine protein < 0.3 g/gCr at biopsy) and Group 2 (urine protein ≥ 0.3 g/gCr at biopsy). Clinical background, histological findings, subsequent treatment selection, and treatment outcomes were compared between the groups. Histological findings were evaluated using the Japanese histological grade classification (H-Grade) and the Oxford classification. For Group 1, we also examined the reasons for performing the renal biopsy and the rationale for treatment selection.
Group 1 was 9 cases. In Group 1, eGFR was significantly higher (92.4 ± 31.4 vs. 62.6 ± 29.8 ml/min/1.73 m², p < 0.05), and proteinuria at the renal biopsy was significantly lower (0.16 ± 0.09 vs. 1.34 ± 1.1 g/gCr, p < 0.05). There were no significant differences between the two groups in the degree of microscopic hematuria and serum IgA levels. In Group 1, the distribution of H-Grade was that I was 77.8%, II was 22.2% and there were no cases of III or IV. The chronic lesions were observed in 77.8%, acute and chronic lesions were observed in 22.2%, and cellular crescents were observed in 2 cases. The 2 cases with acute lesions were characterized by active hematuria and progression of kidney dysfunction. The MEST-C scores of group1 showed M 11.1%, E 0%, S 44.4%, T 11.1%, and C 22.2%. Steroid therapy was initiated in 2/9 cases (22.2%) for Group 1 and in 24/36 cases (66.7%) for Group 2. There were no significant differences between the two groups in ΔeGFR at one year after renal biopsy. In Group 1, reasons for performing renal biopsy included young age and active hematuria. Reasons for initiating steroid therapy included cases of young women who required suppression of disease activity prior to pregnancy and cases where worsening proteinuria was observed during follow-up after renal biopsy.
Even with proteinuria less than 0.3 g/gCr at the time of renal biopsy, some cases showed acute lesions on biopsy. Indication of renal biopsy should be considered based on the patient's background when active hematuria or progressive kidney dysfunction is present.
