IMPACT OF CARDIAC DYSFUNCTION AT INITIATION ON PROGNOSIS IN PATIENTS STARTING PERITONEAL DIALYSIS

 

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https://storage.unitedwebnetwork.com/files/1099/e1b7a46523dc353524b0d31b627616ef.pdf
IMPACT OF CARDIAC DYSFUNCTION AT INITIATION ON PROGNOSIS IN PATIENTS STARTING PERITONEAL DIALYSIS

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Rina
Sanoh
Rina Sanoh rs17863@kchnet.or.jp Kurashiki Central Hospital Nephrology Kurashiki Japan *
Kosuke Fukuoka kf15710@kchnet.or.jp Kurashiki Central Hospital Nephrology Kurashiki Japan -
Akiyuki Zushi az18230@kchnet.or.jp Kurashiki Central Hospital Nephrology Kurashiki Japan -
Toru Mitsuhashi tm18243@kchnet.or.jp Kurashiki Central Hospital Nephrology Kurashiki Japan -
Kyohei Higashi kh17429@kchnet.or.jp Kurashiki Central Hospital Nephrology Kurashiki Japan -
Tomoko Konishi tk17465@kchnet.or.jp Kurashiki Central Hospital Nephrology Kurashiki Japan -
Jiaqi Xu kk17458@kchnet.or.jp Kurashiki Central Hospital Nephrology Kurashiki Japan -
Takahiro Kida tk17005@kchnet.or.jp Kurashiki Central Hospital Nephrology Kurashiki Japan -
Misaki Nakamura mn17480@kchnet.or.jp Kurashiki Central Hospital Nephrology Kurashiki Japan -
Motoyasu Kurahashi mk18254@kchnet.or.jp Kurashiki Central Hospital Nephrology Kurashiki Japan -
Kentaro Watanabe kw17836@kchnet.or.jp Kurashiki Central Hospital Nephrology Kurashiki Japan -
Mana Nishikawa mn13547@kchnet.or.jp Kurashiki Central Hospital Nephrology Kurashiki Japan -
Motoko Kanzaki mk14727@kchnet.or.jp Kurashiki Central Hospital Nephrology Kurashiki Japan -
Kenichiro Asano ka11734@kchnet.or.jp Kurashiki Central Hospital Nephrology Kurashiki Japan -
Noriaki Shimada nshimada@kchnet.or.jp Kurashiki Central Hospital Nephrology Kurashiki Japan -

Cardiac function at the initiation of dialysis may influence subsequent survival. Left ventricular ejection fraction (LVEF) is a well-established prognostic factor in hemodialysis patients, but evidence remains limited in peritoneal dialysis (PD). In addition to systolic function, diastolic dysfunction assessed by the E/e’ ratio has recently gained attention as a prognostic marker in various cardiovascular conditions; however, its prognostic impact in PD patients has not been fully evaluated. This study investigated the influence of both systolic (LVEF) and diastolic function (E/e’) at PD initiation on survival outcomes.

We retrospectively analyzed 143 patients who initiated PD at our institution between 2010 and 2024 ,and had baseline echocardiographic evaluation. Patients were categorized into two groups: reduced cardiac function (LVEF <50%) and preserved cardiac function (LVEF ≥50%). Kaplan–Meier survival analysis and Cox proportional hazards modeling were performed. In a subset of patients, diastolic function was evaluated using the E/e’ ratio, with E/e’ ≥15 defined as impaired diastolic function.

Among 143 patients initiating PD, 22 (15%) had reduced systolic function (LVEF <50%). Survival analysis revealed no significant difference between reduced and preserved LVEF groups (log-rank p=0.75). In multivariate Cox analysis, advanced age (HR 1.086, 95% CI 1.042–1.131, p<0.01), lower serum albumin (HR 0.287, 95% CI 0.122–0.675, p=0.004), and higher CRP (HR 5.608, 95% CI 1.052–29.894, p=0.04) were independent predictors of mortality, whereas reduced LVEF was not.

In the subset evaluated for diastolic function, 41% had elevated E/e′ (≥15). Kaplan–Meier and Cox analyses demonstrated no significant association between impaired diastolic function and survival (log-rank p=0.245; HR 1.011, 95% CI 0.976–1.048, p=0.544).


Cardiac dysfunction at the initiation of PD, including both reduced systolic and impaired diastolic function, was not associated with worse survival. These findings suggest that PD, as a dialysis modality with relatively low cardiac burden, allows stable treatment continuation even in patients with impaired cardiac function. In contrast, malnutrition and inflammation, reflected by low serum albumin and elevated CRP, remained strong determinants of prognosis in PD patients.

Kewords