INFECTIVE ENDOCARDITIS IN HEMODIALYSIS PATIENTS: A REPORT OF TWO CASES ASSOCIATED WITH HEMODIALYSIS ACCESS

 

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INFECTIVE ENDOCARDITIS IN HEMODIALYSIS PATIENTS: A REPORT OF TWO CASES ASSOCIATED WITH HEMODIALYSIS ACCESS

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Somarnam
Somarnam
Somarnam Somarnam corona_mortis82@yahoo.com InaSN Internal Medicine Hasanuddin Universiry Makassar Indonesia *
Haerani Rasyid haeraniabdurasyid@yahoo.com InaSN Internal Medicine Hasanuddin Universiry Makassar Indonesia -
Syakib Bakri syakib.bakri@yahoo.com InaSN Internal Medicine Hasanuddin Universiry Makassar Indonesia -
Hasyim Kasim Hasyimkasim@yahoo.com InaSN Internal Medicine Hasanuddin Universiry Makassar Indonesia -
Nasrum Machmud nasrummachmud29@yahoo.com InaSN Internal Medicine Hasanuddin Universiry Makassar Indonesia -
Sitti Rabiul Zatalia Ramadhan zatalia_ramadhan@yahoo.com InaSN Internal Medicine Hasanuddin Universiry Makassar Indonesia -
Akhyar Albaar rvpakhyarmd@gmail.com InaSN Internal Medicine Hasanuddin Universiry Makassar Indonesia -
Khadijah Khairunnisa ijhasho@gmail.com InaSN Internal Medicine Hasanuddin Universiry Makassar Indonesia -
Achmad Fikry fikryfaridin24@gmail.com InaSN Internal Medicine Hasanuddin Universiry Makassar Indonesia -
 
 
 
 
 
 

Infective endocarditis (IE) is a heart valve infection with high morbidity and mortality rates, particularly among patients with comorbidities. Patients with renal failure  particularly those undergoing hemodialysis (HD), are at high risk due to uremic immunosuppression, comorbid cardiovascular disease and the use of a dialysis access point, such as an arteriovenous fistula (AVF) or a double-lumen catheter (DLC). The long-term use of dialysis access significantly increases the risk of infection. The pathophysiology of IE involves bacterial entry through the access point, adhesions, vegetation formation and heart valve damage. Treatment involves removing the haemodialysis access, administering antibiotics according to the results of sensitivity testing, and ensuring multidisciplinary collaboration. The standard for diagnosing IE is the Modified Duke Criteria.

Observational

Case I: A 30-year-old woman with renal failure  undergoing routine HD was admitted with a fever and shortness of breath. She had been using DLC access for the past 2 months. Her body temperature was 38.1°C and no inflammation was observed at the DLC exit site. Laboratory examination revealed a leukocyte count of 24,050 x 10³/µL. Microbiology: Culture of the catheter tip revealed Methicillin-resistant Staphylococcus epidermidis (MRSE), which was resistant to vancomycin. Echocardiography revealed a large vegetation (2.3 x 1.06 cm) on the tricuspid valve, which supports the diagnosis of infective endocarditis (IE). Management: DLC removal and administration of intravenous ampicillin-sulbactam and gentamicin. 

Case II: A 57-year-old man with renal failure   undergoing HD was admitted with worsening shortness of breath and decreased consciousness (GCS E3V4M2) and a body temperature of 38.7°C. The dialysis access was an AVF in the left arm, cannulated using the buttonhole technique. Microbiology: Blood culture showed growth of Enterococcus faecalis, which was sensitive to ampicillin and vancomycin. Echocardiography revealed a large vegetation (up to 2.31 x 1.62 cm) on the mitral valve.

These two cases demonstrate an association between infected HD  access and the development of IE in patients with rean failure undergoing HD. In both cases, the diagnosis of IE met the Modified Duke Criteria. Managing IE in these cases is challenging due to comorbidities, the risk of resistant organisms (MRSE in Case I) and the need for careful adjustment of the antibiotic dose. Prompt DLC removal and integrated, multidisciplinary management are essential for achieving the best possible outcomes.

Two cases of HD  access-associated infective endocarditis have been reported. The first case involved a 30-year-old woman and the second a 57-year-old man. Both cases met the Modified Duke Criteria.

Kewords