Clinical Characteristics, Diagnostic Strategies, and Long-term Outcomes of Pleuroperitoneal Communication (PPC): A Quarter-Century Longitudinal Study

 

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https://storage.unitedwebnetwork.com/files/1099/b2c01225161e1fb0b171686734642d92.pdf
Clinical Characteristics, Diagnostic Strategies, and Long-term Outcomes of Pleuroperitoneal Communication (PPC): A Quarter-Century Longitudinal Study

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Yen-Ting
Lin
Yen-Ting Lin lucy850409@gmail.com Taipei Veterans General Hospital Nephrology Taipei Taiwan *
Ming-Tsun Tsai mingtsun74@gmail.com Taipei Veterans General Hospital Nephrology Taipei Taiwan -
Szu-Yuan Li syli@vghtpe.gov.tw Taipei Veterans General Hospital Nephrology Taipei Taiwan -
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Hydrothorax is a recognized complication in peritoneal dialysis (PD) patients, with an incidence ranging from 1.6% to 10%. Management strategies include conservative treatment, chemical pleurodesis, and surgical diaphragmatic repair. However, the optimal resting interval after diaphragmatic repair before resuming PD remains unclear. This study aimed to share our institutional experience in managing PD-related hydrothorax at Taipei Veterans General Hospital.

We retrospectively reviewed end-stage renal disease patients who underwent peritoneal dialysis at Taipei Veterans General Hospital between January 2001 and September 2025. A total of 1,130 patients were included. Clinical data regarding hydrothorax management were collected, including treatment modality, recurrence rate, time from surgery to recurrence, and resting interval between diaphragmatic repair and PD resumption.

Among the 1,130 PD patients, 37 (3.27%) developed hydrothorax. The interval between PD initiation and onset of hydrothorax ranged from 1 to 981 days (mean 144.2 days). Management strategies included chemical pleurodesis in 2 patients (5.4%), video-assisted thoracoscopic surgery (VATS) with diaphragmatic repair in 15 patients (40.5%), temporary interruption of PD in 2 patients (5.4%), and permanent transition to hemodialysis in 17 patients (46.0%). One patient continued low-volume PD.

Among the 15 patients who underwent VATS with diaphragmatic repair and pleurodesis, PD was resumed after a mean resting interval of 102.36 days. Two patients (13.3%) experienced recurrence at 130 and 202 days post-repair, respectively

Our findings suggest that a resting interval of approximately three months after VATS diaphragmatic repair allows successful PD resumption with an 86.7% success rate. Further large-scale studies are warranted to determine the optimal timing and refine management strategies for pleuroperitoneal leak in PD patients.

Kewords