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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Insulin resistance is an established risk factor for chronic kidney disease (CKD). The Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), a surrogate marker of insulin resistance, is widely used in population-based studies. However, the sex-specific relationship between insulin resistance, as assessed by HOMA-IR, and kidney function among individuals without CKD remains unclear. This study aimed to evaluate the association between HOMA-IR and estimated glomerular filtration rate (eGFR), sexing male and female participants without CKD.
We conducted a retrospective cross-sectional analysis using data from the 2021–2023 National Health and Nutrition Examination Survey (NHANES). HOMA-IR was calculated as (fasting insulin [µU/mL] × fasting glucose [mg/dL]) ÷ 405 and categorized into tertiles. Estimated glomerular filtration rate (eGFR) was calculated using the CKD-EPI 2021 equation, and participants with eGFR ≤ 60 mL/min/1.73 m² were excluded. Associations between eGFR and HOMA-IR tertiles were examined using multivariable linear regression, adjusting for demographic variables, comorbidities, laboratory parameters, and socioeconomic factors.
Among 2,593 adults included, the mean age was 54.10 ± 16.86 years, 55.38% were female, and 10.80% had diabetes. The median [IQR] HOMA-IR was 0.25 [0.23–0.27], and the median [IQR] eGFR was 96.86 [89.03–109.91] mL/min/1.73 m². In fully adjusted linear regression models, higher HOMA-IR was associated with lower eGFR (β = −5.06, 95% CI −8.15 to −1.98). When categorized into tertiles, participants in the highest HOMA-IR tertile had a greater decline in eGFR compared with those in the lowest tertile (T2: β = −0.61, 95% CI −1.03 to −0.19; p = 0.004; T3: β = −0.94, 95% CI −1.44 to −0.45; p < 0.001). In sex-stratified analyses, the association remained significant among males (T2: β = −0.98, 95% CI −1.03 to −0.34; p = 0.003; T3: β = −1.08, 95% CI −1.78 to −0.37; p = 0.003), whereas among females, it was significant only in the highest tertile (T2: β = −0.27, 95% CI −0.82 to 0.29; p = 0.35; T3: β = −0.99, 95% CI −1.68 to −0.29; p = 0.01).
Using ordinal logistic regression, participants in the highest HOMA-IR tertile also had higher odds of being in a more advanced CKD stage (G2 vs G1) compared with those in the lowest tertile (T2: OR = 1.24, 95% CI 0.73–2.11; p = 0.41; T3: OR = 1.84, 95% CI 1.05–3.21; p = 0.03).
Higher HOMA-IR was independently associated with lower eGFR, particularly among in non-CKD male participants, even after adjusted for diabetes. These findings highlight the need for longitudinal studies to explore the sex-specific mechanisms, such as hormonal alteration, linking insulin resistance to CKD progression.
