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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Histological analysis remains the gold standard for identifying subclinical pathological changes in kidneys prior to kidney donation. In Sri Lanka, no published literature exists on time zero (T0) biopsy findings in kidney donors and recipient outcomes. This is particularly relevant in Sri Lanka, a hotspot for chronic kidney disease of unknown aetiology (CKDu), which may be subclinical at early stages with implications for donation. This study aimed to evaluate the relationship between T0 donor biopsy findings and one-year kidney function among kidney donors and recipients.
This prospective observational study was conducted among 57 kidney recipients and respective donors admitted to Nephrology & Transplant Unit, National Hospital, Kandy. All kidney donors and recipients aged >18 years who consented to participate and had no contraindications for T0 biopsy were included in the study.
The histological abnormalities recorded as glomerulosclerosis, periglomerular fibrosis, tubular atrophy, interstitial fibrosis, vascular fibrous intimal thickening, tubulitis, and interstitial inflammation. If any of these abnormalities were present in the T0 biopsy, they were categorized as "any lesion" in the biopsy. All kidney donors and recipients were reviewed 1, 3, 6, and 12 months post-transplantation.
Among live donors (mean age: 47±8.8 years) 50.9% (n=29) were males and 49.1% (n=28) were females. Histological findings revealed, 52.6% (n=30) of donors had at least one abnormal lesion in their T0 biopsy. At donation, donors with abnormal biopsy findings had a significantly lower estimated glomerular filtration rate (eGFR) (77±18mL/min/1.73m²) compared to those without abnormal histological lesions (84±28mL/min/1.73m²; p=0.01). At one-year follow-up, this difference was no longer significant, with eGFR of 72.4±17.7 and 74.6±16.7mL/min/1.73m² respectively (p=0.64). However, 19.3% (n=11) of the donors had an eGFR <60mL/min/1.73m², which is considered as CKD, and one donor (1.8%) had proteinuria at one year.
Recipients (mean age: 40.1±12.5 years) were predominantly male (71.9%, n=41). Early post-transplant complications included delayed graft function (8.8%, n=5), acute cell-mediated rejection at one month (28.1%, n=16), and antibody-mediated rejection (5.3%, n=3). At one year, 77.2% (n=44) of recipients had no acute rejection episodes. Urinary tract infection was the commonest infection affecting 15.8% (n=9) of recipients in the initial month and persisted throughout the follow-up. At one year, 49.1% (n=28) had eGFR <60mL/min/1.73m² and 3.5% (n=2) had proteinuria. Graft survival was 91.2% (n=52); graft failures (8.8%, n=5) included one requiring haemodialysis (1.8%) and four deaths (7%). Recipients who received kidneys from donors with any lesion had a lower mean eGFR at one-year (58.5±19.9mL/min/1.73m²) compared to those receiving kidneys from donors without lesions (66.4±21.5mL/min/1.73m²), though it was not statistically significant (p=0.17).
Although histological abnormalities in kidney donors were associated with lower eGFR at donation, no significant difference in kidney function was observed between kidney donors and recipients at one-year follow-up. However, a notable proportion of recipients and donors showed reduced kidney function, emphasizing the need for ongoing monitoring and longer follow-up.
