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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
This study aims to explore whether calf circumference, as a measure of muscle mass, has a modifying effect on the relationship between eGFR and all-cause mortality in centenarians.
This prospective study included 967 centenarians from the China Hainan Centenarian Cohort Study. eGFR was calculated using the CKD-EPI 2009 creatinine equation. Participants were grouped by clinical eGFR ranges and sex-specific calf circumference (cutoff: male ≥27 cm, female ≥24 cm). Nonlinear and linear associations were assessed using restricted cubic splines and Cox regression models. The modifying effect of calf circumference was evaluated through subgroup and interaction analyses.
Over a median follow-up of 29.4 months, 896 deaths (92.7%) occurred. RCS analysis revealed a significant U-shaped relationship between eGFR and all-cause mortality in the overall cohort (P-nonlinear < 0.05). Compared to the reference group (eGFR 45–<60 mL/min/1.73 m²), centenarians with eGFR <45 mL/min/1.73 m² had a 42.6% increased risk of mortality (HR = 1.426, 95% CI: 1.201–1.692, P < 0.001). Stratification by calf circumference markedly modified this association (P for interaction < 0.001). In the group with larger calf circumference, the relationship became strongly linear and inverse (HR = 0.857, 95% CI: 0.806–0.910, P < 0.001), whereas no significant association was observed in those with smaller calf circumference.
In centenarians, a lower eGFR (<45 mL/min/1.73 m²) was independently associated with increased all-cause mortality. Crucially, sex-specific calf circumference significantly modified this relationship, such that the association between eGFR and all-cause mortality shifted from a U-shaped to a linear relationship in individuals with larger calf circumferences. These findings suggest that nutrition or muscle reserves, as reflected by calf circumference, may critically influence the link between renal function and survival in the extremely aged, highlighting the need for comprehensive assessment and further mechanistic studies.
