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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
The World Health Organization (WHO) has published guidelines emphasizing the importance of physical training in the prevention and control of chronic non-communicable diseases (NCDs), such as cardiovascular diseases and diabetes mellitus (DM). Diabetic kidney disease (DKD) is one of the main complications of DM. Smoking and DM are two factors that, when combined, exacerbate renal injury. The physycal exercise may improve renal function and attenuate disease progression in individuals with DKD, even when other insults are present. The objetive of this study was to evaluate the effects of moderate physical training on renal function, hemodynamics, and oxidative profile in rats with DKD exposed to nicotine.
Male Wistar rats, weighing between 250-300g, were randomized into groups: Citrate - healthy animals (received 0.4 ml of citrate buffer, vehicle for streptozotocin - STZ - intravenous - i.v.; single dose); Nicotine (NIC) - animals exposed to nicotine (0.6 mg/kg; intraperitoneal-ip; once a day; 28 days); Type 1 Diabetes (DM) - animals that received streptozotocin (60 mg/kg; i.v.; single dose); DM+NIC - DM animals exposed to nicotine; DM+NIC+PT - DM+NIC animals submitted to moderate aerobic PT (swimming; 3 times a week; 50min/day). Body parameters (glycemia; body weight and food intake); renal function (serum creatinine - SCr; inulin clearance - iCl; albuminuria), redox profile (lipid and urinary peroxidation and thiols), renal hemodynamics (mean arterial pressure-MAP; renal vascular resistance-RVR and renal blood flow-RBF) and renal histology were evaluated. Citrate synthase was used as an indicator of mitochondrial content and oxidative capacity in the soleo muscle of the trained groups. Approved by the ethics committee, process nº 2062/2024.
The NIC group showed a decrease in iCl, an increase in sCr and albuminuria. In the DM group, an increase in sCr, a decrease in iCl and albuminuria were observed. The DM group also presented an increase in RVR with a consequent decrease in RBF, with an increase in MAP. Related to the oxidative profile,DM group presented an increase in lipid and urinary peroxidation, elevantion in the urinary nitrite and a decrease in the thiolic antioxidant reserve. The DM+NIC group showed an increase in sCr and albuminuria, an increase in lipid peroxidation and urinary nitrite, an increase in MAP, an increase in RVR and a decrease in RBF, when compared to the DM group. Observing the groups in which PT was applied, NIC+PT, DM+PT and DM+NIC+PT, a renoprotective effect was observed, with a decrease in sCr and albuminuria, in addition to an increase in iCl when compared to the NIC, DM and DM+NIC groups. The renal histology of the diabetic animals presented the highest levels of renal injury score, which was attenuated when PT was instituted.
A combination of diabetes and nicotine resulted in a synergy that was destructive to health, especially of the kidneys.PT demonstrated a renoprotective effect in the DKD, even when combined with nicotine, attenuating functional damage to the kidneys through renal hemodynamic modulation and improvement in the redox profile.A reduction in the renal injury score in the animals in which PT was detected, confirming also a structural renoprotection of the exercise in the DKD combined with nicotine.
