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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Hemodiafiltration (HDF) is more effective at removing middle molecular solutes than high-flux hemodialysis (HD). CONVINCE study showed that high convection volume (CV) HDF resulted in a lower risk of death than high-flux HD. Meta-analysis with individual patient data from 5 randomized studies found that when CV is regarded as a continuous variable (ranging from 15 to 30 liters per session), it shows a negative correlation with the all-cause mortality rate. This result reflects the clinical practice pattern of thrice-weekly HDF in Europe. However, a hybrid treatment pattern with various frequency of HDF and HD in a week is more common in China, resulting in a lower weekly CV dose. The relationship between reduced average weekly convection volume (AWCV) and patient survival in such hybrid regimens remains unclear.
We conducted a retrospective study with all the patients receiving maintenance hemodialysis treatment from July 1st 2020 in two centers of Renji Hospital, Shanghai. Patients were followed up until June 30, 2025. Patient characteristics, labs, post-dialysis weight, net ultrafiltration volume and substitution volume in each session during the study period were collected, as well as patient outcome. We considered the average weekly convection volume (AWCV) as a time-varying covariate, computed over a 6-month or 3-month period. Cox proportional hazards models were fitted using spline terms for AWCV, either univariate or multivariate analysis. Analyses were conducted using R (v2025.05.1) with the mgcv package (v1.9.3).
A total of 530 patients were included, with a mean follow-up of 2.7 years. The AWCV ranged from 0 to 80 L per week. 122 deaths occurred during the follow-up. Both 6-month and 3-month exposures showed an inverse association between AWCV and all-cause mortality risk (P<0.001), persisting after adjustment (P=0.009 and P<0.001 for 6-month and 3-month, respectively, Figure 1). AWCV was negatively correlated with cardiovascular mortality in univariate analysis (P=0.020 and 0.005 for 6-month and 3-month, respectively), although significance was lost after multivariate adjustment (P=0.469 and 0.219, respectively, Figure 1). Subgroup analyses confirmed the inverse association of AWCV with all-cause mortality in both HDF hybrid with low-flux HD and with high-flux HD patients (P<0.05). After adjusting for time-varying post-dialysis weight (30-100 kg) and BSA (1.2-2.2m2), higher AWCV maintained negative correlation with all-cause mortality (P<0.001 for both 6-month and 3-month), with 3-month AWCV exhibiting robust associations (P=0.023 and 0.033 for post-dialysis weight and BSA, respectively).
Higher AWCV, within the range of 0 to 80 L per week, is independently associated with reduced all-cause mortality. These findings provide the initial data on the relationship between weekly CV and survival in patients with a hybrid treatment modality of HDF and conventional HD. These data support further prospective evaluation of individualized HDF dosing strategies.
