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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Technological advancements in transcatheter aortic valve replacement (TAVR) have expanded its indications to include patients at lower surgical risk, underscoring the importance of long-term post-procedural management. Particularly, concerns regarding long-term prognosis and bioprosthetic valve durability in dialysis patients with aortic stenosis (AS) are significant challenges to TAVR, as they are to surgical AVR. In this study, we re-examined the association between hypomagnesemia and elevated mean aortic pressure gradients-an indicator of bioprosthetic valve deterioration (SVD), which we previously reported in a small cohort. Using long-term follow-up data from a larger, accumulated case series, we also analyzed post-procedural survival and the prognostic impact of cardiac function.
We analyzed 100 dialysis patients who underwent TAVR at Osaka University Hospital between April 2012 and November 2021. Data from preoperative laboratory tests, periodic postoperative echocardiography, and survival status were analyzed using linear mixed-effects models and time-dependent Cox regression analysis.
Over a maximum follow-up of 10.6 years, an increase in the mean pressure gradient of the bioprosthetic valve was consistently associated with preoperative hypomagnesemia (linear mixed-effects model; +1.55 mmHg/year per 1 mg/dl lower in Mg, p=0.001) SVD was diagnosed in seven patients, with a higher tendency in the hypomagnesemia group; however, hypomagnesemia was not associated with mortality. During the observation period, 77 patients died. The mean mean age at the end of follow-up was 81.5 ± 6.8 years. The observed survival appeared to exceed the life expectancy anticipated from the mean age at dialysis initiation (69.4 ± 12.4 years). Consistent with previous reports, preoperative Left Ventricular Ejection Fraction (LVEF) was associated with survival, with an increased risk observed in patients with LVEF <40%. Although the low LVEF group (<55%) showed a significant postoperative improvement in LVEF, this improvement did not impact prognosis.
Hypomagnesemia is likely associated with the development of SVD after TAVR but does not affect long-term survival. While TAVR may improve the prognosis of dialysis patients, our findings underscore the importance of considering the intervention before a significant decline in LVEF occurs.
