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During the congress, E-Posters will be accessible to all participants on the congress website 24/7, as well as in the E-poster stations in the congress center.
Preparing your E-Poster
Please review the E-Poster format requirements carefully when preparing your E-Poster. Should your E-Poster not meet the mentioned requirements, it may not be displayed as described above.
E-Poster Submission Deadline
Please prepare and upload your E-Poster no later than March 14, 2026 11.59PM CET. After this date, you will no longer be able to prepare and upload your E-poster and it will not be displayed and accessible on the congress website.
Please follow the instructions below to input your abstract title.
Abstract titles should be brief and reflect the content of the abstract.
Cardiovascular-kidney-metabolic (CKM) syndrome is a health disorder due to heart disease, kidney disease, type 2 diabetes and obesity. This study aims to investigate the associations between dietary risk factors and mortality outcomes in patients with CKM.
We conducted a population-based cohort study utilizing data, 19,297 US participants aged ≥20 years and 100,745 UK participants aged ≥40 years from the US National Health and Nutrition Examination Survey (NHANES; 2001–2018) and the UK Biobank (2006–2024). Participants were classified into CKM stages 0 through 4. Dietary risk factors including sugar, sodium, total fat, saturated fatty acids (SFA), vitamins of A, C, and E, zinc, selenium, and carotenoids were stratified by energy proportion. A composite dietary antioxidant index (CDAI) was calculated from absolute intake levels. Participants were categorized into quartiles for analysis. Mortality outcomes, including all-cause and cardiovascular mortality, were obtained from the National Death Index for the US NHANES or National Health Service records for the UK Biobank.
In NHANES, individuals in the highest quartile of sugar intake exhibited a significantly increased risk of all-cause mortality compared to those in the lowest quartile (RR = 3.34 [1.15 to 9.67]). Elevated intake of glucose, sodium, and SFA was associated with higher risks of both all-cause and cardiovascular mortality among CKM stages 1–3, following nonlinear dose-response relationships (P-nonlinear < 0.05). Conversely, higher intake of vitamins A, C, E, carotenoids, selenium, zinc, and CDAI demonstrated protective effects, reducing all-cause mortality by approximately 31% in NHANES and 20–25% in the UK Biobank compared to the lowest quartiles; these protective effects increased with greater intake (P-nonlinear < 0.01). Mediation analyses indicated that selenium and vitamin E accounted for approximately -15.45% and -10.47% of the sodium-mortality association in UK CKM stage 2 participants, respectively, while CDAI mediated a 12.56% reduction in mortality risk among NHANES stage 1 participants by moderating sodium’s effect. No significant associations were observed in stages 0 and 4.
In CKM stages 1–3, high intake of sugar, sodium, and SFA significantly elevates mortality risk, whereas increased consumption of dietary antioxidants and a higher CDAI confer protective effects that can partially offset dietary risks. Stage-specific, precision dietary interventions during early to moderate CKM are crucial for optimizing patient outcomes.
