Lower level of Vitamin D associated with High MAP in the early stage of CKD, A Study from CKD Community in East Java

 

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Lower level of Vitamin D associated with High MAP in the early stage of CKD, A Study from CKD Community in East Java

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Satriyo Dwi
Suryantoro
Satriyo Dwi Suryantoro satriyo.dwi.suryantoro@fk.unair.ac.id Faculty of Medicine, Airlangga University Doctoral Program of Internal Medicine Surabaya Indonesia *
Mochamad Thaha mochthaha@fk.unair.ac.id Faculty of Medicine, Airlangga University Department of Internal Medicine Surabaya Indonesia -
Mutiara Rizky Haryati drmutiara.rh@gmail.com Faculty of Medicine, Airlangga University Department of Internal Medicine Surabaya Indonesia -
Bagus Aulia Mahdi bagusauliamahdi@um-surabaya.ac.id Faculty of Medicine, Muhammadiyah University Department of Internal Medicine Surabaya Indonesia -
Ulinnuha Qurrota A’yunin ayuninulin@gmail.com Faculty of Medicine, Airlangga University Department of Internal Medicine Surabaya Indonesia -
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Renal artery stiffness is associated with elevated mean arterial pressure (MAP). However, in Indonesia, there are very limited studies investigating the relationship between 25-hydroxyvitamin D [25(OH)D] levels and renal disease progression in early-stage chronic kidney disease (CKD stages 1–4). Background/Objectives: To analyze the relationship between 25(OH)D levels and MAP in early-stage CKD patients. 

This was an observational analytic cross-sectional study of patients with CKD stages 1–4 recruited from a CKD community in East Java. Statistical analysis was performed using comparative analysis between groups.

This study included 85 patients with CKD stages 2–4 (mean age, 58.38 years). The mean 25(OH)D level was 28.26 ng/mL, and the mean MAP was 122.31 mmHg. Patients with lower 25(OH)D levels (<30 ng/mL; n=40) had a significantly higher MAP of 124.51 mmHg compared to those with normal 25(OH)D levels (n=45; MAP, 120.33 mmHg; p=0.03).

Lower vitamin D levels in early-stage CKD patients are associated with elevated mean arterial pressure.

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